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    SERK2 somatic embryogenesis receptor-like kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840320, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SERK2
    Official Full Name
    somatic embryogenesis receptor-like kinase 2
    Primary source
    TAIR:AT1G34210
    Locus tag
    AT1G34210
    See related
    Araport:AT1G34210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSERK2; F23M19.11; F23M19_11; somatic embryogenesis receptor-like kinase 2
    Summary
    Plasma membrane LRR receptor-like serine threonine kinase expressed during embryogenesis in locules until stage 6 anthers, with higher expression in the tapetal cell layer. SERK1 and SERK2 receptor kinases function redundantly as an important control point for sporophytic development controlling male gametophyte production.
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    Genomic context

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    See SERK2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (12458564..12462905)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene NAC domain containing protein 17 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase-like family protein Neighboring gene Regulator of Vps4 activity in the MVB pathway protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis thaliana SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASES1 and 2 control male sporogenesis. Albrecht C, et al. Plant Cell, 2005 Dec. PMID 16284305, Free PMC Article
    2. Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR KINASES1 and 2 are essential for tapetum development and microspore maturation. Colcombet J, et al. Plant Cell, 2005 Dec. PMID 16284306, Free PMC Article
    3. CLE42 binding induces PXL2 interaction with SERK2. Mou S, et al. Protein Cell, 2017 Aug. PMID 28677102, Free PMC Article
    4. Two SERK Receptor-Like Kinases Interact with EMS1 to Control Anther Cell Fate Determination. Li Z, et al. Plant Physiol, 2017 Jan. PMID 27920157, Free PMC Article
    5. Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation. Bojar D, et al. Plant J, 2014 Apr. PMID 24461462, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In this study, we show that loss of function of SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE (SERK) genes results in aberrant embryo development. Fewer cortical, endodermal, and vascular cells are generated in the embryos of serk1 serk2 bak1 triple mutants.
      Title: SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis.
    2. CLE42 binding induces PXL2 interaction with SERK2.
      Title: CLE42 binding induces PXL2 interaction with SERK2.
    3. these data provide genetic and biochemical evidence of the interaction and phosphorylation between SERK1/2 and EMS1 in anther development.
      Title: Two SERK Receptor-Like Kinases Interact with EMS1 to Control Anther Cell Fate Determination.
    4. SERK1 or SERK2 extracellular domains are essential for SERK function in male sporogenesis, while the SERK3 extracellular and cytoplasmic domains are essential for SERK3 activity in brassinosteroid and flagellin signaling.
      Title: On the Origin of SERKs: Bioinformatics Analysis of the Somatic Embryogenesis Receptor Kinases.
    5. A protein interaction surface on the C-terminal lobe of the kinase is identified and demonstrate that the isolated BRI1, SERK2 and SERK3 cytoplasmic segments form homodimers in solution and have a weak tendency to heteromerise.
      Title: Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001333091.1
    NM_103144.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brassinosteroid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microsporogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within microsporogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plant ovule development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    somatic embryogenesis receptor-like kinase 2
    NP_174683.1
    • somatic embryogenesis receptor-like kinase 2 (SERK2); FUNCTIONS IN: kinase activity; INVOLVED IN: pollen maturation, microsporogenesis; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: somatic embryogenesis receptor-like kinase 1 (TAIR:AT1G71830.1); Has 175230 Blast hits to 121098 proteins in 4288 species: Archae - 125; Bacteria - 16192; Metazoa - 44525; Fungi - 8981; Plants - 85819; Viruses - 391; Other Eukaryotes - 19197 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      12458564..12462905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103144.5 → NP_174683.1  somatic embryogenesis receptor-like kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174683.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94F63, Q9XIC7
      UniProtKB/TrEMBL
      A0A5S9WIQ1, A0A654EGU8
      Conserved Domains (3) summary
      PLN00113
      Location:32 → 185
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:98 → 121
      LRR_RI; leucine-rich repeat [structural motif]
      cl21453
      Location:311 → 582
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001333091.1 → NP_001320467.1  somatic embryogenesis receptor-like kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94F63, Q9XIC7
      UniProtKB/TrEMBL
      A0A5S9WIQ1, A0A654EGU8
      Conserved Domains (3) summary
      PLN00113
      Location:32 → 185
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:98 → 121
      LRR_RI; leucine-rich repeat [structural motif]
      cl21453
      Location:311 → 582
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XIC7.1

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