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    SHA SH2 domain protein A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838274, updated on 18-Sep-2024

    Summary

    Official Symbol
    SHA
    Official Full Name
    SH2 domain protein A
    Primary source
    TAIR:AT1G17040
    Locus tag
    AT1G17040
    See related
    Araport:AT1G17040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA SH2 DOMAIN PROTEIN A; ATSHA; F20D23.26; F20D23_26; SH2 domain protein A; STAT-TYPE LINKER-SH2 DOMAIN FACTOR A; STATLA
    Summary
    Encodes a protein that contains an SH2 domain. It can pull down a 120-kD tyrosine-phosphorylated protein in vitro. It is predicted to act as a transcription factor.
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    Genomic context

    See SHA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (5824771..5828266)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene senescence-related gene 1 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene solanesyl diphosphate synthase 2 Neighboring gene uncharacterized protein Neighboring gene cytochrome p450 72c1

    General gene information

    NM_001198089.1
    NM_101564.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
     

    General protein information

    Preferred Names
    SH2 domain protein A
    NP_001185018.1
    • SH2 domain protein A (SHA); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity, signal transducer activity; INVOLVED IN: signal transduction, regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: SH2 motif (InterPro:IPR000980), STAT transcription factor, core (InterPro:IPR001217), Concanavalin A-like lectin/glucanase (InterPro:IPR008985); BEST Arabidopsis thaliana protein match is: SH2 domain protein B (TAIR:AT1G78540.1).
    NP_173147.2
    • SH2 domain protein A (SHA); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity, signal transducer activity; INVOLVED IN: signal transduction, regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: SH2 motif (InterPro:IPR000980), STAT transcription factor, core (InterPro:IPR001217), Concanavalin A-like lectin/glucanase (InterPro:IPR008985); BEST Arabidopsis thaliana protein match is: SH2 domain protein B (TAIR:AT1G78540.1); Has 341 Blast hits to 335 proteins in 60 species: Archae - 0; Bacteria - 0; Metazoa - 258; Fungi - 0; Plants - 45; Viruses - 0; Other Eukaryotes - 38 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5824771..5828266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332274.1NP_001321275.1  SH2 domain protein A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WKF6
    2. NM_101564.4NP_173147.2  SH2 domain protein A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173147.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8AQE5, B5X561, F4I632, Q9SHG3
      UniProtKB/TrEMBL
      A0A178WKF6
      Conserved Domains (2) summary
      cd10338
      Location:536641
      SH2_SHA; Src homology 2 (SH2) domain found in SH2 adaptor proteins A (SHA) Signal transducers
      cl22861
      Location:20168
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    3. NM_001198089.1NP_001185018.1  SH2 domain protein A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WKF6
      Conserved Domains (2) summary
      cd10338
      Location:546651
      SH2_SHA; Src homology 2 (SH2) domain found in SH2 adaptor proteins A (SHA) Signal transducers
      cl22861
      Location:20178
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...