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    Plau plasminogen activator, urokinase [ Mus musculus (house mouse) ]

    Gene ID: 18792, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plauprovided by MGI
    Official Full Name
    plasminogen activator, urokinaseprovided by MGI
    Primary source
    MGI:MGI:97611
    See related
    Ensembl:ENSMUSG00000021822 AllianceGenome:MGI:97611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    uPA; u-PA
    Summary
    Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including fibrinolysis; response to hypoxia; and smooth muscle cell migration. Part of serine-type endopeptidase complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and trophectoderm. Used to study Alzheimer's disease; hepatocellular carcinoma; and steatotic liver disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 100.9), bladder adult (RPKM 27.0) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Plau in Genome Data Viewer
    Location:
    14 A3; 14 11.53 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20886730..20893456)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20836662..20843388)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase II gamma Neighboring gene STARR-seq mESC enhancer starr_36118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:21604587-21604774 Neighboring gene STARR-seq mESC enhancer starr_36120 Neighboring gene predicted gene, 30108 Neighboring gene H3 histone, family 3A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7298 Neighboring gene STARR-seq mESC enhancer starr_36123 Neighboring gene STARR-seq mESC enhancer starr_36124 Neighboring gene predicted gene, 30212

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase activity  
    enables protein binding PubMed 
    enables serine-type endopeptidase activity  
    enables serine-type endopeptidase activity  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in fibrinolysis  
    acts_upstream_of_or_within fibrinolysis PubMed 
    involved_in negative regulation of fibrinolysis PubMed 
    involved_in negative regulation of plasminogen activation PubMed 
    involved_in plasminogen activation  
    involved_in plasminogen activation  
    involved_in plasminogen activation  
    acts_upstream_of_or_within positive regulation of cell migration PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of reactive oxygen species metabolic process  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in regulation of cell adhesion  
    involved_in regulation of cell adhesion mediated by integrin  
    involved_in regulation of cell adhesion mediated by integrin  
    involved_in regulation of cell adhesion mediated by integrin  
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    involved_in regulation of fibrinolysis PubMed 
    involved_in regulation of hepatocyte proliferation  
    involved_in regulation of plasminogen activation PubMed 
    involved_in regulation of signaling receptor activity  
    involved_in regulation of smooth muscle cell migration  
    involved_in regulation of smooth muscle cell migration  
    involved_in regulation of smooth muscle cell-matrix adhesion  
    involved_in regulation of smooth muscle cell-matrix adhesion  
    acts_upstream_of_or_within response to hypoxia PubMed 
    involved_in skeletal muscle tissue regeneration  
    acts_upstream_of_or_within smooth muscle cell migration PubMed 
    involved_in urokinase plasminogen activator signaling pathway PubMed 
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    located_in cell surface  
    located_in external side of plasma membrane PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    part_of protein complex involved in cell-matrix adhesion  
    part_of serine protease inhibitor complex  
    part_of serine-type endopeptidase complex PubMed 
    part_of serine-type endopeptidase complex  

    General protein information

    Preferred Names
    urokinase-type plasminogen activator
    Names
    U-plasminogen activator
    NP_032899.1
    XP_017171408.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008873.3NP_032899.1  urokinase-type plasminogen activator precursor

      See identical proteins and their annotated locations for NP_032899.1

      Status: VALIDATED

      Source sequence(s)
      BY320655, X02389
      Consensus CDS
      CCDS26858.1
      UniProtKB/Swiss-Prot
      P06869
      UniProtKB/TrEMBL
      Q0VBA8
      Related
      ENSMUSP00000022368.3, ENSMUST00000022368.4
      Conserved Domains (2) summary
      cd00190
      Location:180424
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:71152
      Kringle; Kringle domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20886730..20893456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315919.3XP_017171408.1  urokinase-type plasminogen activator isoform X1

      UniProtKB/Swiss-Prot
      P06869
      UniProtKB/TrEMBL
      Q0VBA8
      Conserved Domains (2) summary
      cd00190
      Location:180424
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:71152
      Kringle; Kringle domain
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