Megf9 multiple EGF-like-domains 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Megf9provided by MGI
Official Full Name: multiple EGF-like-domains 9provided by MGI
Primary source: MGI:MGI:1918264
See related: Ensembl:ENSMUSG00000039270 AllianceGenome:MGI:1918264
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Egfl5; mKIAA0818; 9630025C07; 4933405H16Rik
Summary: Predicted to be involved in several processes, including axon guidance; basement membrane assembly; and substrate adhesion-dependent cell spreading. Located in basement membrane. Is expressed in several structures, including eye; gut epithelium; nervous system; olfactory epithelium; and skin. Orthologous to human MEGF9 (multiple EGF like domains 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 10.3), whole brain E14.5 (RPKM 9.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C2; 4 35.92 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (70350164..70453165, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (70431927..70534928, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEGF9 represents a novel putative receptor, expressed in neuronal and non-neuronal tissues, that is regulated during development and could function as a guidance or signalling molecule.
Title: MEGF9: a novel transmembrane protein with a strong and developmentally regulated expression in the nervous system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

G67012 (e-PCR)
- UniSTS:178218

NoName (e-PCR)
- UniSTS:234943

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in basement membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
part_of laminin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: multiple epidermal growth factor-like domains protein 9

Names: EGF-like protein 5; EGF-like-domain, multiple 5; epidermal growth factor-like protein 5; multiple EGF-like domains protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172694.2 → NP_766282.1 multiple epidermal growth factor-like domains protein 9 precursor

See identical proteins and their annotated locations for NP_766282.1

Status: PROVISIONAL

Source sequence(s)

AK035987

Consensus CDS

CCDS18273.1

UniProtKB/Swiss-Prot

Q8BH27, Q8BWI4

UniProtKB/TrEMBL

Q0VGR4

Related

ENSMUSP00000102982.3, ENSMUST00000107359.9

Conserved Domains (5) summary

cd00055
Location:251 → 295

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:202 → 245

Laminin_EGF; Laminin EGF domain

pfam08418
Location:75 → 199

Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

pfam11235
Location:39 → 185

Med25_SD1; Mediator complex subunit 25 synapsin 1

pfam12238
Location:129 → 182

MSA-2c; Merozoite surface antigen 2c