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    NRT1:2 nitrate transporter 1:2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843321, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NRT1:2
    Official Full Name
    nitrate transporter 1:2
    Primary source
    TAIR:AT1G69850
    Locus tag
    AT1G69850
    See related
    Araport:AT1G69850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABA-importing transporter 1; AIT1; AtNPF4.6; ATNRT1:2; nitrate transporter 1:2; NPF4.6; NRT1.2; NRT1/ PTR family 4.6; NTL1; T17F3.12; T17F3_12
    Summary
    Encodes an inducible component of low-affinity nitrate uptake. mRNA found primarily in root hairs and the epidermis of roots. It also acts as an ABA importer at the site of ABA biosynthesis and is important for the regulation of stomatal aperture in inflorescence stems.
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    Genomic context

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    See NRT1:2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (26296540..26300684, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene alpha-amylase-like 3 Neighboring gene SPFH/Band 7/PHB domain-containing membrane-associated protein family Neighboring gene ncRNA Neighboring gene Major facilitator superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ABA-importing transporter (AIT1) synergies enhances exogenous ABA minimize heavy metals accumulations in Arabidopsis. Zhu Y, et al. J Hazard Mater, 2024 Jul 15. PMID 38797079
    2. Abscisic acid (ABA)-importing transporter 1 (AIT1) contributes to the inhibition of Cd accumulation via exogenous ABA application in Arabidopsis. Pan W, et al. J Hazard Mater, 2020 Jun 5. PMID 32044630
    3. Nitrate does not compete with abscisic acid as a substrate of AtNPF4.6/NRT1.2/AIT1 in Arabidopsis. Kanno Y, et al. Plant Signal Behav, 2013. PMID 24084651, Free PMC Article
    4. Identification of an abscisic acid transporter by functional screening using the receptor complex as a sensor. Kanno Y, et al. Proc Natl Acad Sci U S A, 2012 Jun 12. PMID 22645333, Free PMC Article
    5. Arabidopsis NPF4.6 and NPF5.1 Control Leaf Stomatal Aperture by Regulating Abscisic Acid Transport. Shimizu T, et al. Genes (Basel), 2021 Jun 8. PMID 34201150, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABA-importing transporter (AIT1) synergies enhances exogenous ABA minimize heavy metals accumulations in Arabidopsis.
      Title: ABA-importing transporter (AIT1) synergies enhances exogenous ABA minimize heavy metals accumulations in Arabidopsis.
    2. Arabidopsis NPF4.6 and NPF5.1 Control Leaf Stomatal Aperture by Regulating Abscisic Acid Transport.
      Title: Arabidopsis NPF4.6 and NPF5.1 Control Leaf Stomatal Aperture by Regulating Abscisic Acid Transport.
    3. Regulation of the stability and ABA import activity of NRT1.2/NPF4.6 by CEPR2-mediated phosphorylation in Arabidopsis.
      Title: Regulation of the stability and ABA import activity of NRT1.2/NPF4.6 by CEPR2-mediated phosphorylation in Arabidopsis.
    4. Arabidopsis NRT1.2 interacts with the PHOSPHOLIPASE Dalpha1 (PLDalpha1) to positively regulate seed germination and seedling development in response to ABA treatment.
      Title: Arabidopsis NRT1.2 interacts with the PHOSPHOLIPASE Dα1 (PLDα1) to positively regulate seed germination and seedling development in response to ABA treatment.
    5. Abscisic acid (ABA)-importing transporter 1 (AIT1) contributes to the inhibition of Cd accumulation via exogenous ABA application in Arabidopsis.
      Title: Abscisic acid (ABA)-importing transporter 1 (AIT1) contributes to the inhibition of Cd accumulation via exogenous ABA application in Arabidopsis.
    6. These results do not support the idea of a physiological linkage between nitrate and ABA signals through AtNPF4.6.
      Title: Nitrate does not compete with abscisic acid as a substrate of AtNPF4.6/NRT1.2/AIT1 in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_105653.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables abscisic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nematode HEP PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nitrate transporter 1:2
    NP_564978.1
    • nitrate transporter 1:2 (NRT1:2); FUNCTIONS IN: transporter activity, calcium ion binding; INVOLVED IN: response to nematode; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oligopeptide transporter (InterPro:IPR000109), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: Major facilitator superfamily protein (TAIR:AT1G27040.1); Has 5870 Blast hits to 5639 proteins in 1033 species: Archae - 0; Bacteria - 2327; Metazoa - 503; Fungi - 400; Plants - 2186; Viruses - 0; Other Eukaryotes - 454 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26296540..26300684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105653.5 → NP_564978.1  nitrate transporter 1:2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564978.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81393, Q8H157, Q8W4N9, Q9CAR8
      UniProtKB/TrEMBL
      A0A178W7G0, A0A5S9WR62, A0A654EP98
      Conserved Domains (1) summary
      cd17414
      Location:29 → 575
      MFS_NPF4; NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H157.1

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