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    AAT1 amino acid transporter 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827860, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AAT1
    Official Full Name
    amino acid transporter 1
    Primary source
    TAIR:AT4G21120
    Locus tag
    AT4G21120
    See related
    Araport:AT4G21120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    amino acid transporter 1; AtCAT1; CAT1; CATIONIC AMINO ACID TRANSPORTER 1; F7J7.60; F7J7_60
    Summary
    Encodes a member of the cationic amino acid transporter (CAT) subfamily of amino acid polyamine choline transporters. Mediates efficient uptake of Lys, Arg and Glu in a yeast system.
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    Genomic context

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    See AAT1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (11269985..11274007)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene damaged DNA binding protein 1B Neighboring gene cytochrome-c oxidase/ electron carrier Neighboring gene G10 family protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene copper ion-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Seed and vascular expression of a high-affinity transporter for cationic amino acids in Arabidopsis. Frommer WB, et al. Proc Natl Acad Sci U S A, 1995 Dec 19. PMID 8618839, Free PMC Article
    2. Molecular and functional characterization of a family of amino acid transporters from Arabidopsis. Su YH, et al. Plant Physiol, 2004 Oct. PMID 15377779, Free PMC Article
    3. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    4. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001341473.1
    NM_118231.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables L-lysine transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables basic amino acid transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables basic amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-arginine import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within basic amino acid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    amino acid transporter 1
    NP_193844.2
    • amino acid transporter 1 (AAT1); FUNCTIONS IN: arginine transmembrane transporter activity, L-lysine transmembrane transporter activity, cationic amino acid transmembrane transporter activity, L-glutamate transmembrane transporter activity; INVOLVED IN: basic amino acid transport, L-arginine import, L-glutamate import; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Cationic amino acid transporter (InterPro:IPR015606), Amino acid/polyamine transporter I (InterPro:IPR002293), Cationic amino acid transport permease (InterPro:IPR004755), Amino acid permease domain (InterPro:IPR004841); BEST Arabidopsis thaliana protein match is: cationic amino acid transporter 5 (TAIR:AT2G34960.1); Has 31468 Blast hits to 31317 proteins in 2259 species: Archae - 510; Bacteria - 25893; Metazoa - 1955; Fungi - 1722; Plants - 342; Viruses - 0; Other Eukaryotes - 1046 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11269985..11274007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118231.4 → NP_193844.2  amino acid transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193844.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7DLY7, Q84MA5, Q96241
      UniProtKB/TrEMBL
      A0A178UYU0, A0A5S9XUU6, A0A654FRB2
      Conserved Domains (1) summary
      TIGR00906
      Location:58 → 565
      2A0303; cationic amino acid transport permease

    2. NM_001341473.1 → NP_001328597.1  amino acid transporter 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B561
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84MA5.1

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