CRT1 compromized recognition of TCV 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CRT1
Official Full Name: compromized recognition of TCV 1
Primary source: TAIR:AT4G36290
Locus tag: AT4G36290
See related: Araport:AT4G36290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtMORC1; compromised recognition of TCV 1; F23E13.180; F23E13_180; Microchidia 1; MORC1
Summary: R-protein-interacting protein that localizes to endosomes and functions in resistance gene#Aeimediated immunity. Belongs to the conserved Microrchidia (MORC) adenosine triphosphatase (ATPase) family, predicted to catalyze alterations in chromosome superstructure. Required for heterochromatin condensation and gene silencing.
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Genomic context

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See CRT1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 18

Sequence:: Chromosome: 4; NC_003075.7 (17169385..17173361, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA polymerase epsilon binds histone H3.1-H4 and recruits MORC1 to mediate meiotic heterochromatin condensation.
Title: DNA polymerase epsilon binds histone H3.1-H4 and recruits MORC1 to mediate meiotic heterochromatin condensation.
These results provide evidence that MORC1 is associated with TEs and suggest that a subset of these transposable elements (TEs) may help regulate their proximal defense genes.
Title: Pathogen Infection and MORC Proteins Affect Chromatin Accessibility of Transposable Elements and Expression of Their Proximal Genes in Arabidopsis.
The abnormal phenotype of the cnx1 crt1 crt2 crt3 quadruple mutants was completely rescued by either the CNX1 or CNX2 cDNA under the control of the CNX1 promoter, suggesting functional redundancy between CNX1 and CNX2. Taken together, these results provide genetic evidence that CNX and CRT play essential and overlapping roles during vegetative growth and male gametophyte development in Arabidopsis
Title: Systematic deletion of the ER lectin chaperone genes reveals their roles in vegetative growth and male gametophyte development in Arabidopsis.
Mutations in AtMORC1 and AtMORC6 cause derepression of DNA-methylated genes and transposable elements but no losses of DNA or histone methylation; AtMORC1 and AtMORC6 are members of the conserved Microrchidia (MORC) ATPase family, which are predicted to catalyze alterations in chromosome superstructure. [MORC1]
Title: MORC family ATPases required for heterochromatin condensation and gene silencing.
role in pathogen-associated molecular pattern (PAMP)-triggered immunity, basal resistance, non-host resistance and systemic acquired resistance
Title: CRT1 is a nuclear-translocated MORC endonuclease that participates in multiple levels of plant immunity.
CRT1, an ATPase, is an important mediator of defense signaling triggered by distinct classes of R proteins. [CRT1]
Title: CRT1, an Arabidopsis ATPase that interacts with diverse resistance proteins and modulates disease resistance to turnip crinkle virus.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_119797.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of systemic acquired resistance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: compromized recognition of TCV 1

NP_568000.1

compromised recognition of TCV 1 (CRT1); CONTAINS InterPro DOMAIN/s: ATPase-like, ATP-binding domain (InterPro:IPR003594); BEST Arabidopsis thaliana protein match is: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein (TAIR:AT4G36280.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

17169385..17173361 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119797.4 → NP_568000.1 compromized recognition of TCV 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568000.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23245, O65520, Q56WA8, Q84WV6, Q9C5D9

UniProtKB/TrEMBL

A0A654FW16

Conserved Domains (2) summary

pfam17942
Location:332 → 470

Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

cl00075
Location:91 → 212

HATPase; Histidine kinase-like ATPase domain