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    UXS1 UDP-glucuronic acid decarboxylase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824520, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UXS1
    Official Full Name
    UDP-glucuronic acid decarboxylase 1
    Primary source
    TAIR:AT3G53520
    Locus tag
    AT3G53520
    See related
    Araport:AT3G53520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATUXS1; UDP-glucuronic acid decarboxylase 1
    Summary
    Encodes an isoform of UDP-glucuronic acid decarboxylase, which is predicted to be membrane-bound by PSORT analysis. This enzyme produces UDP-xylose, which is a substrate for many cell wall carbohydrates including hemicellulose and pectin. UDP-xylose is also known to feedback regulate several cell wall biosynthetic enzymes.
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    Genomic context

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    See UXS1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (19841374..19844412)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene valine-tRNA ligase Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein with retrovirus zinc finger-like domain-containing protein Neighboring gene ABC-2 type transporter family protein Neighboring gene ncRNA Neighboring gene Chloroplast-targeted copper chaperone protein Neighboring gene afadin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of UDP-xylose. Cloning and characterization of a novel Arabidopsis gene family, UXS, encoding soluble and putative membrane-bound UDP-glucuronic acid decarboxylase isoforms. Harper AD, et al. Plant Physiol, 2002 Dec. PMID 12481102, Free PMC Article
    2. Role of UDP-Glucuronic Acid Decarboxylase in Xylan Biosynthesis in Arabidopsis. Kuang B, et al. Mol Plant, 2016 Aug 1. PMID 27179920
    3. Label-free protein quantification for plant Golgi protein localization and abundance. Nikolovski N, et al. Plant Physiol, 2014 Oct. PMID 25122472, Free PMC Article
    4. Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization. Parsons HT, et al. Plant Cell, 2019 Sep. PMID 31266899, Free PMC Article
    5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001084808.1
    NM_001203151.1
    NM_115212.3
    NM_180363.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucuronate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucuronate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-xylose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-xylose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-D-xylose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in Golgi trans cisterna HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in endosome HDA PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    UDP-glucuronic acid decarboxylase 1
    NP_001078277.1
    • UDP-glucuronic acid decarboxylase 1 (UXS1); FUNCTIONS IN: UDP-glucuronate decarboxylase activity, catalytic activity; INVOLVED IN: nucleotide-sugar metabolic process, D-xylose metabolic process; LOCATED IN: Golgi apparatus, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G62830.2); Has 38083 Blast hits to 38064 proteins in 2955 species: Archae - 783; Bacteria - 23043; Metazoa - 704; Fungi - 289; Plants - 1309; Viruses - 79; Other Eukaryotes - 11876 (source: NCBI BLink).
    NP_001190080.1
    • UDP-glucuronic acid decarboxylase 1 (UXS1); CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: UDP-xylose synthase 4 (TAIR:AT2G47650.2).
    NP_190920.3
    • UDP-glucuronic acid decarboxylase 1 (UXS1); FUNCTIONS IN: UDP-glucuronate decarboxylase activity, catalytic activity; INVOLVED IN: nucleotide-sugar metabolic process, D-xylose metabolic process; LOCATED IN: Golgi apparatus, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G62830.2); Has 44451 Blast hits to 44420 proteins in 2995 species: Archae - 846; Bacteria - 26140; Metazoa - 764; Fungi - 351; Plants - 1482; Viruses - 93; Other Eukaryotes - 14775 (source: NCBI BLink).
    NP_850694.2
    • UDP-glucuronic acid decarboxylase 1 (UXS1); FUNCTIONS IN: UDP-glucuronate decarboxylase activity, catalytic activity; INVOLVED IN: nucleotide-sugar metabolic process, D-xylose metabolic process; LOCATED IN: Golgi apparatus, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G62830.2); Has 47365 Blast hits to 47309 proteins in 3022 species: Archae - 864; Bacteria - 27567; Metazoa - 790; Fungi - 366; Plants - 1585; Viruses - 98; Other Eukaryotes - 16095 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19841374..19844412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203151.1 → NP_001190080.1  UDP-glucuronic acid decarboxylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190080.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XM61, A0A654FFG3, F4JAG3
      Conserved Domains (2) summary
      PLN02166
      Location:1 → 458
      PLN02166; dTDP-glucose 4,6-dehydratase
      cd05230
      Location:121 → 446
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs

    2. NM_180363.3 → NP_850694.2  UDP-glucuronic acid decarboxylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850694.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EAK3, Q8VZC0, Q9LFG7
      UniProtKB/TrEMBL
      A0A178V9J6, A0A5S9XM61, A0A654FFG3
      Conserved Domains (1) summary
      PLN02166
      Location:1 → 435
      PLN02166; dTDP-glucose 4,6-dehydratase

    3. NM_001084808.1 → NP_001078277.1  UDP-glucuronic acid decarboxylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078277.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H4I6
      Conserved Domains (2) summary
      pfam01370
      Location:122 → 338
      Epimerase; NAD dependent epimerase/dehydratase family
      cl21454
      Location:121 → 337
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. NM_115212.3 → NP_190920.3  UDP-glucuronic acid decarboxylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190920.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XM61, A0A654FFG3
      Conserved Domains (2) summary
      PLN02166
      Location:1 → 433
      PLN02166; dTDP-glucose 4,6-dehydratase
      cd05230
      Location:121 → 421
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VZC0.1

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