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    MES5 methyl esterase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830894, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MES5
    Official Full Name
    methyl esterase 5
    Primary source
    TAIR:AT5G10300
    Locus tag
    AT5G10300
    See related
    Araport:AT5G10300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA METHYL ESTERASE 5; AtHNL; ATMES5; F18D22.70; F18D22_70; HNL; HYDROXYNITRILE LYASE; methyl esterase 5
    Summary
    Encodes a protein with R-selective hydroxynitrile lyase activity. It has similarity to the SABP2 methyl salicylate esterase from tobacco. This protein does not act on methyl IAA, methyl JA, MeSA, MeGA4, or MEGA9 in vitro.
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    Genomic context

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    See MES5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (3239455..3240883)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene myb domain protein 92 Neighboring gene leucine-rich repeat transmembrane protein kinase family protein Neighboring gene EPIDERMAL PATTERNING FACTOR-like protein Neighboring gene ATP synthase subunit B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hydroxynitrile lyase defends Arabidopsis against Tetranychus urticae. Arnaiz A, et al. Plant Physiol, 2022 Aug 1. PMID 35474139, Free PMC Article
    2. A QM/MM study of the reaction mechanism of (R)-hydroxynitrile lyases from Arabidopsis thaliana (AtHNL). Zhu W, et al. Proteins, 2015 Jan. PMID 25052541
    3. Hydroxynitrile lyases with α/β-hydrolase fold: two enzymes with almost identical 3D structures but opposite enantioselectivities and different reaction mechanisms. Andexer JN, et al. Chembiochem, 2012 Sep 3. PMID 22851196, Free PMC Article
    4. Synthesis of (R)-β-nitro alcohols catalyzed by R-selective hydroxynitrile lyase from Arabidopsis thaliana in the aqueous-organic biphasic system. Fuhshuku K, et al. J Biotechnol, 2011 May 20. PMID 21439333
    5. A downstream mediator in the growth repression limb of the jasmonate pathway. Yan Y, et al. Plant Cell, 2007 Aug. PMID 17675405, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The catalytic mechanism of AtHNL was theoretically studied based on the recently obtained crystal structure in.
      Title: A QM/MM study of the reaction mechanism of (R)-hydroxynitrile lyases from Arabidopsis thaliana (AtHNL).
    2. Determined is the structure of the recently identified, R-selective HYDROXYNITRILE LYASE from Arabidopsis thaliana at a crystallographic resolution of 2.5 A.
      Title: Hydroxynitrile lyases with α/β-hydrolase fold: two enzymes with almost identical 3D structures but opposite enantioselectivities and different reaction mechanisms.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001343099.1
    NM_121068.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mandelonitrile lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to insect IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycoside catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methyl esterase 5
    NP_196592.1
    • methyl esterase 5 (MES5); CONTAINS InterPro DOMAIN/s: Alpha/beta hydrolase fold-1 (InterPro:IPR000073); BEST Arabidopsis thaliana protein match is: methyl esterase 1 (TAIR:AT2G23620.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3239455..3240883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121068.4 → NP_196592.1  methyl esterase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93Z57, Q94AI5, Q9LFT6
      UniProtKB/TrEMBL
      A0A178U928, A0A5S9Y3I3, A0A654FZU5, A0A7G2F7A8
      Conserved Domains (1) summary
      PLN02211
      Location:3 → 250
      PLN02211; methyl indole-3-acetate methyltransferase

    2. NM_001343099.1 → NP_001332228.1  methyl esterase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BGG9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LFT6.1

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