Garem1 GRB2 associated regulator of MAPK1 subtype 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Garem1provided by MGI
Official Full Name: GRB2 associated regulator of MAPK1 subtype 1provided by MGI
Primary source: MGI:MGI:2685790
See related: Ensembl:ENSMUSG00000042680 AllianceGenome:MGI:2685790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Garem; Gm944; Fam59a; mKIAA4238
Summary: Predicted to enable proline-rich region binding activity. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade. Is expressed in central nervous system; heart; lung; metanephros; and skeletal musculature. Orthologous to human GAREM1 (GRB2 associated regulator of MAPK1 subtype 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 4.4), frontal lobe adult (RPKM 4.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A2; 18 11.87 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (21257916..21433196, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (21127342..21300139, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GAREM1 is involved in controlling body mass in mice and humans.
Title: GAREM1 is involved in controlling body mass in mice and humans.
Data indicate that a subtype of GAREM, GAREM2, is specifically expressed in the mouse, rat, and human brain.
Title: A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Markers

RH127272 (e-PCR)
- UniSTS:209810

D18Mit132 (e-PCR), detects polymorphism
- UniSTS:128151

D18Mit132.2 (e-PCR), detects polymorphism
- UniSTS:128152

RH126099 (e-PCR)
- UniSTS:162811

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables proline-rich region binding	IBA Inferred from Biological aspect of Ancestor more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein kinase activity by regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within response to epidermal growth factor	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: GRB2-associated and regulator of MAPK protein

Names: GRB2 associated, regulator of MAPK1; GRB2-associated and regulator of MAPK1; family with sequence similarity 59, member A; protein FAM59A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.