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    CNGC4 cyclic nucleotide-gated cation channel 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835513, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CNGC4
    Official Full Name
    cyclic nucleotide-gated cation channel 4
    Primary source
    TAIR:AT5G54250
    Locus tag
    AT5G54250
    See related
    Araport:AT5G54250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCNGC4; cyclic nucleotide-gated cation channel 4; DEFENSE; DND2; HLM1; MDK4.7; MDK4_7; NO DEATH 2
    Summary
    member of Cyclic nucleotide gated channel family, downstream component of the signaling pathways leading to HR resistance. mutant plants exhibit gene-for-gene disease resistance against avirulent Pseudomonas syringae despite the near-complete absence of the hypersensitive response (HR). Salicylic acid accumulation in dnd2 mutants is completely PAD4-independent.
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    Genomic context

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    See CNGC4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (22025035..22030099, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myb domain protein 49 Neighboring gene membrane lipoprotein lipid attachment site-like protein, putative (DUF1223) Neighboring gene DNA repair and meiosis protein (Mre11) Neighboring gene light-harvesting chlorophyll B-binding protein 3 Neighboring gene myosin 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural variation in CYCLIC NUCLEOTIDE-GATED ION CHANNEL 4 reveals a novel role of calcium signaling in vegetative phase change in Arabidopsis. Wang X, et al. New Phytol, 2024 May. PMID 38184789
    2. HLM1, an essential signaling component in the hypersensitive response, is a member of the cyclic nucleotide-gated channel ion channel family. Balagué C, et al. Plant Cell, 2003 Feb. PMID 12566578, Free PMC Article
    3. A calmodulin-gated calcium channel links pathogen patterns to plant immunity. Tian W, et al. Nature, 2019 Aug. PMID 31316205
    4. Crossroads of stress responses, development and flowering regulation--the multiple roles of Cyclic Nucleotide Gated Ion Channel 2. Fortuna A, et al. Plant Signal Behav, 2015. PMID 25719935, Free PMC Article
    5. The Arabidopsis cyclic nucleotide-gated ion channels AtCNGC2 and AtCNGC4 work in the same signaling pathway to regulate pathogen defense and floral transition. Chin K, et al. Plant Physiol, 2013 Oct. PMID 24027242, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Natural variation in CYCLIC NUCLEOTIDE-GATED ION CHANNEL 4 reveals a novel role of calcium signaling in vegetative phase change in Arabidopsis.
      Title: Natural variation in CYCLIC NUCLEOTIDE-GATED ION CHANNEL 4 reveals a novel role of calcium signaling in vegetative phase change in Arabidopsis.
    2. CNGC-mediated calcium entry thus provides a critical link between the pattern-recognition receptor complex and calcium-dependent immunity programs in the PAMP-triggered immunity signalling pathway in plants
      Title: A calmodulin-gated calcium channel links pathogen patterns to plant immunity.
    3. This indicates that AtCNGC2 and AtCNGC4 have a unique role controlling flowering timing and this function is independent from its role in pathogen defense.
      Title: Crossroads of stress responses, development and flowering regulation--the multiple roles of Cyclic Nucleotide Gated Ion Channel 2.
    4. AtCNGC2 and AtCNGC4 are likely part of the same channel complex.
      Title: The Arabidopsis cyclic nucleotide-gated ion channels AtCNGC2 and AtCNGC4 work in the same signaling pathway to regulate pathogen defense and floral transition.
    5. The findings indicate that the broad-spectrum resistance of dnd2 mutants occurs due to activation or sensitization of multiple defense pathways, yet none of the investigated pathways are required for the reduced-HR phenotype.
      Title: Signaling pathways that regulate the enhanced disease resistance of Arabidopsis "defense, no death" mutants.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001203607.1
    NM_001345080.1
    NM_124805.3
    NM_180857.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables monoatomic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic nucleotide-gated cation channel 4
    NP_001190536.1
    • cyclic nucleotide-gated cation channel 4 (CNGC4); FUNCTIONS IN: cation transmembrane transporter activity, cyclic nucleotide binding, calmodulin binding, cation channel activity; INVOLVED IN: plant-type hypersensitive response; LOCATED IN: membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710); BEST Arabidopsis thaliana protein match is: Cyclic nucleotide-regulated ion channel family protein (TAIR:AT5G15410.1).
    NP_200236.1
    • cyclic nucleotide-gated cation channel 4 (ATCNGC4); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710); BEST Arabidopsis thaliana protein match is: Cyclic nucleotide-regulated ion channel family protein (TAIR:AT5G15410.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_851188.1
    • cyclic nucleotide-gated cation channel 4 (CNGC4); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710); BEST Arabidopsis thaliana protein match is: Cyclic nucleotide-regulated ion channel family protein (TAIR:AT5G15410.2); Has 13099 Blast hits to 4876 proteins in 392 species: Archae - 0; Bacteria - 175; Metazoa - 8070; Fungi - 607; Plants - 1352; Viruses - 290; Other Eukaryotes - 2605 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22025035..22030099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124805.3 → NP_200236.1  cyclic nucleotide-gated cation channel 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200236.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AS9, Q9XFS2
      UniProtKB/TrEMBL
      A0A178UAK7, B9DFK7
      Conserved Domains (2) summary
      COG0664
      Location:490 → 611
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:496 → 602
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    2. NM_001345080.1 → NP_001332114.1  cyclic nucleotide-gated cation channel 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AS9, Q9XFS2
      UniProtKB/TrEMBL
      A0A178UAK7, B9DFK7

    3. NM_001203607.1 → NP_001190536.1  cyclic nucleotide-gated cation channel 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UAK7, F4K0A1
      Conserved Domains (2) summary
      COG0664
      Location:485 → 606
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:493 → 597
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    4. NM_180857.2 → NP_851188.1  cyclic nucleotide-gated cation channel 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851188.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AS9, Q9XFS2
      UniProtKB/TrEMBL
      A0A178UAK7, B9DFK7
      Conserved Domains (2) summary
      COG0664
      Location:490 → 611
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:496 → 602
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AS9.2

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