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    ChaC-like family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832691, updated on 18-Sep-2024

    Summary

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    Official Full Name
    ChaC-like family protein
    Primary source
    TAIR:AT5G26220
    Locus tag
    AT5G26220
    See related
    Araport:AT5G26220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtGGCT2;1; gamma-glutamyl cyclotransferase 2;1; GGCT2;1; T19G15.70; T19G15_70
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (9162969..9164884, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene Mitochondrial substrate carrier family protein Neighboring gene alfin-like 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene membrane-associated kinase regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome profiling reveals similarities and differences in plant responses to cadmium and lead. Kovalchuk I, et al. Mutat Res, 2005 Mar 1. PMID 15708574
    2. Arabidopsis γ-glutamylcyclotransferase affects glutathione content and root system architecture during sulfur starvation. Joshi NC, et al. New Phytol, 2019 Feb. PMID 30368820
    3. A γ-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis. Paulose B, et al. Plant Cell, 2013 Nov. PMID 24214398, Free PMC Article
    4. Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana: role of the ChaC/GCG family of γ-glutamyl cyclotransferases as glutathione-degrading enzymes and AtLAP1 as the Cys-Gly peptidase. Kumar S, et al. Biochem J, 2015 May 15. PMID 25716890
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results point to a role for GGCT2;1 in Sulfur-starvation-response changes to root system architecture through activity of the gamma-glutamyl cycle in the primary root tip. [GGCT2;1]
      Title: Arabidopsis γ-glutamylcyclotransferase affects glutathione content and root system architecture during sulfur starvation.
    2. At5g26220 plays a role in detoxification of heavy metals and metalloids by recycling glutamate to maintain glutathione homeostasis.
      Title: A γ-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001343968.1
    NM_122523.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables gamma-glutamylcyclotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gamma-glutamylcyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glutathione catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to lead ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ChaC-like family protein
    NP_197994.1
    • ChaC-like family protein; CONTAINS InterPro DOMAIN/s: ChaC-like protein (InterPro:IPR006840); BEST Arabidopsis thaliana protein match is: ChaC-like family protein (TAIR:AT4G31290.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9162969..9164884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122523.4 → NP_197994.1  ChaC-like family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GY54
      UniProtKB/TrEMBL
      A0A5S9Y7V9, A0A654G524, O81489
      Conserved Domains (1) summary
      cl22886
      Location:3 → 181
      GGCT_like; GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is ...

    2. NM_001343968.1 → NP_001332737.1  ChaC-like family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1R7T3I6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GY54.1

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