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    LON1 lon protease 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832744, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LON1
    Official Full Name
    lon protease 1
    Primary source
    TAIR:AT5G26860
    Locus tag
    AT5G26860
    See related
    Araport:AT5G26860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2P16.23; F2P16_23; lon protease 1; LON_ARA_ARA
    Summary
    Encodes a member of the Lon protease-like proteins (Lon1/At5g26860, Lon2/At5g47040, Lon3/At3g05780, Lon4/At3g05790). Lon is a multifunctional ATP-dependent protease which exists in bacteria, archaea and within organelles in eukaryotic cells. Lon proteases are responsible for the degradation of abnormal, damaged and unstable proteins.
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    Genomic context

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    See LON1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    19
    Sequence:
    Chromosome: 5; NC_003076.8 (9450952..9457000)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene AGAMOUS-like MADS-box protein Neighboring gene tRNA (cytidine(34)-2'-O)-methyltransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changes in specific protein degradation rates in Arabidopsis thaliana reveal multiple roles of Lon1 in mitochondrial protein homeostasis. Li L, et al. Plant J, 2017 Feb. PMID 27726214
    2. Alternative transcription initiation and the AUG context configuration control dual-organellar targeting and functional competence of Arabidopsis Lon1 protease. Daras G, et al. Mol Plant, 2014 Jun. PMID 24646630
    3. Loss of Lon1 in Arabidopsis changes the mitochondrial proteome leading to altered metabolite profiles and growth retardation without an accumulation of oxidative damage. Solheim C, et al. Plant Physiol, 2012 Nov. PMID 22968828, Free PMC Article
    4. Role of Lon1 protease in post-germinative growth and maintenance of mitochondrial function in Arabidopsis thaliana. Rigas S, et al. New Phytol, 2009. PMID 19076295
    5. A cytoplasmic male sterility-associated mitochondrial peptide in common bean is post-translationally regulated. Sarria R, et al. Plant Cell, 1998 Jul. PMID 9668139, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate roles of Lon1 as a chaperone aiding the proper folding of newly synthesized/imported proteins to stabilise them and as a protease to degrade mitochondrial protein aggregates.
      Title: Changes in specific protein degradation rates in Arabidopsis thaliana reveal multiple roles of Lon1 in mitochondrial protein homeostasis.
    2. Data postulate that Lon1 and its subfunctional paralog Lon4 evolved complementary subsets of transcriptional and posttranscriptional regulatory components responsive to environmental cues for dual-organellar targeting.
      Title: Alternative transcription initiation and the AUG context configuration control dual-organellar targeting and functional competence of Arabidopsis Lon1 protease.
    3. Loss of Lon1 significantly modifies respiratory function and plant performance by small but broad alterations in the mitochondrial proteome.
      Title: Loss of Lon1 in Arabidopsis changes the mitochondrial proteome leading to altered metabolite profiles and growth retardation without an accumulation of oxidative damage.
    4. These results shed light on the developmental mechanisms of selective proteolysis in plant mitochondria and suggest a critical role for AtLon1 protease in organelle biogenesis and seedling establishment.
      Title: Role of Lon1 protease in post-germinative growth and maintenance of mitochondrial function in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122568.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    lon protease 1
    NP_568490.4
    • lon protease 1 (LON1); FUNCTIONS IN: serine-type peptidase activity, protein binding, ATP-dependent peptidase activity, ATP binding; INVOLVED IN: proteolysis; LOCATED IN: cytosol, mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), Peptidase S16, active site (InterPro:IPR008268), Peptidase S16, ATP-dependent protease La (InterPro:IPR004815), Peptidase S16, lon N-terminal (InterPro:IPR003111), Peptidase S16, Lon C-terminal (InterPro:IPR008269), ATPase, AAA+ type, core (InterPro:IPR003593), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), Peptidase S16, Lon protease, C-terminal (InterPro:IPR001984); BEST Arabidopsis thaliana protein match is: lon protease 4 (TAIR:AT3G05790.1); Has 18238 Blast hits to 18056 proteins in 2534 species: Archae - 547; Bacteria - 9804; Metazoa - 746; Fungi - 600; Plants - 445; Viruses - 7; Other Eukaryotes - 6089 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9450952..9457000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122568.4 → NP_568490.4  lon protease 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04954, P93655, Q8RWX1
      UniProtKB/TrEMBL
      A0A2H1ZE77, A0A654G4C9
      Conserved Domains (1) summary
      TIGR00763
      Location:146 → 978
      lon; endopeptidase La
    Nucleotide Protein
    Heading Accession and Version

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