Asb15 ankyrin repeat and SOCS box-containing 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asb15provided by MGI
Official Full Name: ankyrin repeat and SOCS box-containing 15provided by MGI
Primary source: MGI:MGI:1926160
See related: Ensembl:ENSMUSG00000029685 AllianceGenome:MGI:1926160
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Asb-15; 4930400E23Rik
Summary: Predicted to enable chloroplast targeting sequence binding activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway; positive regulation of JNK cascade; and protein targeting to chloroplast. Predicted to be active in nucleus. Is expressed in genitourinary system; quadriceps femoris muscle; thoracic segment skeleton; and tongue. Orthologous to human ASB15 (ankyrin repeat and SOCS box containing 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in heart adult (RPKM 14.4), testis adult (RPKM 4.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.1; 6 11.28 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (24528143..24573163)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (24528144..24573164)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ASB15 has a role in early myoblast differentiation and that its effects may be mediated in part by the PI3K/Akt signal transduction pathway
Title: Ankyrin repeat and suppressor of cytokine signaling (SOCS) box-containing protein (ASB) 15 alters differentiation of mouse C2C12 myoblasts and phosphorylation of mitogen-activated protein kinase and Akt.
Results suggest ASB15 participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells.
Title: Ankyrin repeat and SOCS box protein 15 regulates protein synthesis in skeletal muscle.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chloroplast targeting sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to chloroplast	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ankyrin repeat and SOCS box protein 15

Names: ankyrin repeat and SOCS box-containing protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080847.3 → NP_543123.2 ankyrin repeat and SOCS box protein 15

Status: VALIDATED

Source sequence(s)

AK019556, AK029759, AK079418, AK142748

Consensus CDS

CCDS19943.1

UniProtKB/Swiss-Prot

Q8CDP8, Q8VHS6

UniProtKB/TrEMBL

Q8C565

Related

ENSMUSP00000031696.4, ENSMUST00000031696.10

Conserved Domains (5) summary

PHA02875
Location:99 → 271

PHA02875; ankyrin repeat protein; Provisional

sd00045
Location:178 → 207

ANK; ANK repeat [structural motif]

pfam12796
Location:47 → 141

Ank_2; Ankyrin repeats (3 copies)

cl02533
Location:532 → 583

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl39094
Location:211 → 440

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

24528143..24573163

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241089.3 → XP_011239391.1 ankyrin repeat and SOCS box protein 15 isoform X4

UniProtKB/Swiss-Prot

Q8CDP8, Q8VHS6

UniProtKB/TrEMBL

Q8C565

Conserved Domains (5) summary

PHA02875
Location:99 → 271

PHA02875; ankyrin repeat protein; Provisional

sd00045
Location:178 → 207

ANK; ANK repeat [structural motif]

pfam12796
Location:47 → 141

Ank_2; Ankyrin repeats (3 copies)

cl02533
Location:532 → 583

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl39094
Location:211 → 440

Ank_2; Ankyrin repeats (3 copies)
XM_036152406.1 → XP_036008299.1 ankyrin repeat and SOCS box protein 15 isoform X1

UniProtKB/TrEMBL

Q8C565

Conserved Domains (4) summary

PHA02875
Location:121 → 293

PHA02875; ankyrin repeat protein; Provisional

sd00045
Location:200 → 229

ANK; ANK repeat [structural motif]

pfam12796
Location:269 → 358

Ank_2; Ankyrin repeats (3 copies)

cl02533
Location:554 → 605

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_006505206.4 → XP_006505269.1 ankyrin repeat and SOCS box protein 15 isoform X3

UniProtKB/TrEMBL

Q8C565

Conserved Domains (5) summary

PHA02875
Location:116 → 288

PHA02875; ankyrin repeat protein; Provisional

sd00045
Location:195 → 224

ANK; ANK repeat [structural motif]

pfam12796
Location:64 → 158

Ank_2; Ankyrin repeats (3 copies)

cl02533
Location:549 → 600

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl39094
Location:228 → 457

Ank_2; Ankyrin repeats (3 copies)
XM_036152407.1 → XP_036008300.1 ankyrin repeat and SOCS box protein 15 isoform X2

UniProtKB/TrEMBL

Q8C565

Conserved Domains (4) summary

PHA02875
Location:120 → 292

PHA02875; ankyrin repeat protein; Provisional

sd00045
Location:199 → 228

ANK; ANK repeat [structural motif]

pfam12796
Location:268 → 357

Ank_2; Ankyrin repeats (3 copies)

cl02533
Location:553 → 604

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...