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    SPHK1 sphingosine kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828239, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPHK1
    Official Full Name
    sphingosine kinase 1
    Primary source
    TAIR:AT4G21540
    Locus tag
    AT4G21540
    See related
    Araport:AT4G21540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F18E5.160; F18E5_160; sphingosine kinase 1
    Summary
    Encodes a sphingosine kinase, also has enzyme activity towards other plant long-chain sphingoid bases. Involved in guard cell ABA signalling and seed germination.
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    Genomic context

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    See SPHK1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (11459228..11462651)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene Diacylglycerol kinase family protein Neighboring gene ncRNA Neighboring gene VP1/ABI3-like 3 Neighboring gene vacuolar protein sorting-associated protein-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of novel phosphatidic acid binding domain on sphingosine kinase 1 of Arabidopsis thaliana. Pandit S, et al. Plant Physiol Biochem, 2018 Jul. PMID 29783183
    2. Sphingosine kinase AtSPHK1 functions in fumonisin B1-triggered cell death in Arabidopsis. Qin X, et al. Plant Physiol Biochem, 2017 Oct. PMID 28846870
    3. Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases. Guo L, et al. J Biol Chem, 2011 Apr 15. PMID 21330371, Free PMC Article
    4. Involvement of sphingosine kinase in plant cell signalling. Worrall D, et al. Plant J, 2008 Oct. PMID 18557834, Free PMC Article
    5. Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture. Coursol S, et al. Plant Physiol, 2005 Feb. PMID 15665242, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of amino acids (182)VSGDGI(187) perturbed PA-AtSPHK1 binding, indicating an essential role of these six amino acids in PA-AtSPHK1 binding.
      Title: Identification of novel phosphatidic acid binding domain on sphingosine kinase 1 of Arabidopsis thaliana.
    2. findings indicate a role of SPHK1 in modulating FB1-triggered cell death via SA and JA pathway interactions.
      Title: Sphingosine kinase AtSPHK1 functions in fumonisin B1-triggered cell death in Arabidopsis.
    3. SPHK/phyto-S1P and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.
      Title: Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis.
    4. Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.
      Title: Involvement of sphingosine kinase in plant cell signalling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001036612.2
    NM_001341496.1
    NM_118274.8

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables D-erythro-sphingosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-erythro-sphingosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables sphingosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to abscisic acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sphingosine kinase 1
    NP_001031689.2
    • sphingosine kinase 1 (SPHK1); FUNCTIONS IN: diacylglycerol kinase activity, sphinganine kinase activity, D-erythro-sphingosine kinase activity; INVOLVED IN: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, seed germination, response to abscisic acid stimulus; LOCATED IN: plant-type vacuole membrane, vacuole; CONTAINS InterPro DOMAIN/s: Diacylglycerol kinase, catalytic domain (InterPro:IPR001206); BEST Arabidopsis thaliana protein match is: Diacylglycerol kinase family protein (TAIR:AT4G21534.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001320022.1
    • sphingosine kinase 1 (SPHK1); FUNCTIONS IN: diacylglycerol kinase activity, sphinganine kinase activity, D-erythro-sphingosine kinase activity; INVOLVED IN: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, seed germination, response to abscisic acid stimulus; LOCATED IN: plant-type vacuole membrane, vacuole; CONTAINS InterPro DOMAIN/s: Diacylglycerol kinase, catalytic domain (InterPro:IPR001206); BEST Arabidopsis thaliana protein match is: Diacylglycerol kinase family protein (TAIR:AT4G21534.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_193885.6
    • sphingosine kinase 1 (SPHK1); FUNCTIONS IN: diacylglycerol kinase activity, sphinganine kinase activity, D-erythro-sphingosine kinase activity; INVOLVED IN: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, seed germination, response to abscisic acid stimulus; LOCATED IN: plant-type vacuole membrane, vacuole; CONTAINS InterPro DOMAIN/s: Diacylglycerol kinase, catalytic domain (InterPro:IPR001206); BEST Arabidopsis thaliana protein match is: Diacylglycerol kinase family protein (TAIR:AT4G21534.1); Has 6888 Blast hits to 3984 proteins in 1156 species: Archae - 1; Bacteria - 4291; Metazoa - 1136; Fungi - 331; Plants - 472; Viruses - 0; Other Eukaryotes - 657 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11459228..11462651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118274.8 → NP_193885.6  sphingosine kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193885.6

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A2H1ZEN6, F4JJK0, O65419, Q8L7L1
      UniProtKB/TrEMBL
      A0A178V174, A0A5S9XWM0, A0A654FRG1
      Conserved Domains (1) summary
      PLN02958
      Location:8 → 485
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

    2. NM_001341496.1 → NP_001320022.1  sphingosine kinase 1 [Arabidopsis thaliana]

      Status: REVIEWED

    3. NM_001036612.2 → NP_001031689.2  sphingosine kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031689.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JJK1
      Conserved Domains (1) summary
      cl01255
      Location:1 → 275
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L7L1.1

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