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    EIN4 Signal transduction histidine kinase, hybrid-type, ethylene sensor [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819614, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EIN4
    Official Full Name
    Signal transduction histidine kinase, hybrid-type, ethylene sensor
    Primary source
    TAIR:AT3G04580
    Locus tag
    AT3G04580
    See related
    Araport:AT3G04580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ETHYLENE INSENSITIVE 4; F7O18.5; F7O18_5
    Summary
    Ethylene receptor, subfamily 2. Has serine kinase activity.
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    Genomic context

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    See EIN4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (1235209..1238630, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene nucleolar/coiled-body phosphoprotein Neighboring gene ncRNA Neighboring gene AT-hook motif nuclear-localized protein 19 Neighboring gene AT hook motif DNA-binding family protein Neighboring gene Nucleotidylyl transferase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EIN4 and ERS2 are members of the putative ethylene receptor gene family in Arabidopsis. Hua J, et al. Plant Cell, 1998 Aug. PMID 9707532, Free PMC Article
    2. Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana. Hua J, et al. Cell, 1998 Jul 24. PMID 9695954
    3. Ethylene Regulates Levels of Ethylene Receptor/CTR1 Signaling Complexes in Arabidopsis thaliana. Shakeel SN, et al. J Biol Chem, 2015 May 8. PMID 25814663, Free PMC Article
    4. Arabidopsis ETR1 and ERS1 differentially repress the ethylene response in combination with other ethylene receptor genes. Liu Q, et al. Plant Physiol, 2012 Mar. PMID 22227969, Free PMC Article
    5. Ethylene receptor ETHYLENE RECEPTOR1 domain requirements for ethylene responses in Arabidopsis seedlings. Kim H, et al. Plant Physiol, 2011 May. PMID 21386032, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ETR1, ETR2, and ETHYLENE INSENSITIVE4 (EIN4) have the prominent roles in rapid growth recovery after removal of ethylene whereas ETR1 was the sole isoform that rescued nutations.
      Title: Ethylene receptor ETHYLENE RECEPTOR1 domain requirements for ethylene responses in Arabidopsis seedlings.
    2. Both ETR1 and EIN4 are predominantly required for the repression of ethylene responses by ERS1.
      Title: Arabidopsis ETR1 and ERS1 differentially repress the ethylene response in combination with other ethylene receptor genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111329.4
    NM_202489.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ethylene binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ethylene receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of ethylene-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Signal transduction histidine kinase, hybrid-type, ethylene sensor
    NP_187108.1
    • ETHYLENE INSENSITIVE 4 (EIN4); FUNCTIONS IN: ethylene binding, protein histidine kinase activity, receptor activity, glycogen synthase kinase 3 activity; INVOLVED IN: negative regulation of ethylene mediated signaling pathway; LOCATED IN: endomembrane system, endoplasmic reticulum membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, hybrid-type, ethylene sensor (InterPro:IPR014525), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), ATPase-like, ATP-binding domain (InterPro:IPR003594), GAF (InterPro:IPR003018); BEST Arabidopsis thaliana protein match is: Signal transduction histidine kinase, hybrid-type, ethylene sensor (TAIR:AT3G23150.1); Has 63350 Blast hits to 57717 proteins in 2870 species: Archae - 286; Bacteria - 55528; Metazoa - 15; Fungi - 1532; Plants - 2041; Viruses - 18; Other Eukaryotes - 3930 (source: NCBI BLink).
    NP_974218.1
    • ETHYLENE INSENSITIVE 4 (EIN4); FUNCTIONS IN: ethylene binding, protein histidine kinase activity, receptor activity, glycogen synthase kinase 3 activity; INVOLVED IN: negative regulation of ethylene mediated signaling pathway; LOCATED IN: endomembrane system, endoplasmic reticulum membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, hybrid-type, ethylene sensor (InterPro:IPR014525), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), ATPase-like, ATP-binding domain (InterPro:IPR003594), GAF (InterPro:IPR003018); BEST Arabidopsis thaliana protein match is: Signal transduction histidine kinase, hybrid-type, ethylene sensor (TAIR:AT3G23150.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1235209..1238630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111329.4 → NP_187108.1  Signal transduction histidine kinase, hybrid-type, ethylene sensor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187108.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZTP3
      UniProtKB/TrEMBL
      A0A178VKQ4, A0A5S9X909, A0A7G2EM58
      Conserved Domains (4) summary
      smart00388
      Location:367 → 432
      HisKA; His Kinase A (phosphoacceptor) domain
      cd16938
      Location:473 → 610
      HATPase_ETR2_ERS2-EIN4-like; Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains
      cd19933
      Location:642 → 757
      REC_ETR-like; phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins
      pfam01590
      Location:181 → 331
      GAF; GAF domain

    2. NM_202489.2 → NP_974218.1  Signal transduction histidine kinase, hybrid-type, ethylene sensor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974218.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZTP3
      UniProtKB/TrEMBL
      A0A178VKQ4, A0A5S9X909, A0A7G2EM58
      Conserved Domains (4) summary
      smart00388
      Location:367 → 432
      HisKA; His Kinase A (phosphoacceptor) domain
      cd16938
      Location:473 → 610
      HATPase_ETR2_ERS2-EIN4-like; Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains
      cd19933
      Location:642 → 757
      REC_ETR-like; phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins
      pfam01590
      Location:181 → 331
      GAF; GAF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZTP3.1

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