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    TPK2 thiamine pyrophosphokinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819084, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TPK2
    Official Full Name
    thiamine pyrophosphokinase 2
    Primary source
    TAIR:AT2G44750
    Locus tag
    AT2G44750
    See related
    Araport:AT2G44750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F16B22.24; thiamin pyrophosphokinase 2
    Summary
    Encodes a thiamine pyrophosphokinase capable of producing thiamine pyrophosphate from free thiamine.
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    Genomic context

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    See TPK2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (18451426..18452875)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene WRKY family transcription factor Neighboring gene dihydroorotate dehydrogenase (DUF3598) Neighboring gene ELMO/CED-12 family protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thiamin pyrophosphokinase is required for thiamin cofactor activation in Arabidopsis. Ajjawi I, et al. Plant Mol Biol, 2007 Sep. PMID 17611796
    2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_130040.3
    NM_180093.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables thiamine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine diphosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within thiamine metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thiamine pyrophosphokinase 2
    NP_566026.1
    • thiamin pyrophosphokinase 2 (TPK2); CONTAINS InterPro DOMAIN/s: Thiamin pyrophosphokinase, vitamin B1-binding domain (InterPro:IPR007373), Thiamin pyrophosphokinase, eukaryotic (InterPro:IPR016966), Thiamin pyrophosphokinase (InterPro:IPR006282), Thiamin pyrophosphokinase, catalytic domain (InterPro:IPR007371); BEST Arabidopsis thaliana protein match is: thiamin pyrophosphokinase1 (TAIR:AT1G02880.3); Has 1413 Blast hits to 1411 proteins in 581 species: Archae - 0; Bacteria - 767; Metazoa - 135; Fungi - 134; Plants - 93; Viruses - 0; Other Eukaryotes - 284 (source: NCBI BLink).
    NP_850424.1
    • thiamin pyrophosphokinase 2 (TPK2); CONTAINS InterPro DOMAIN/s: Thiamin pyrophosphokinase, vitamin B1-binding domain (InterPro:IPR007373), Thiamin pyrophosphokinase, eukaryotic (InterPro:IPR016966), Thiamin pyrophosphokinase (InterPro:IPR006282), Thiamin pyrophosphokinase, catalytic domain (InterPro:IPR007371); BEST Arabidopsis thaliana protein match is: thiamin pyrophosphokinase1 (TAIR:AT1G02880.3); Has 1352 Blast hits to 1350 proteins in 558 species: Archae - 0; Bacteria - 721; Metazoa - 134; Fungi - 134; Plants - 93; Viruses - 0; Other Eukaryotes - 270 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18451426..18452875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180093.2 → NP_850424.1  thiamine pyrophosphokinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850424.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IV16, O80514, Q94B25
      UniProtKB/TrEMBL
      A0A5S9X710, A0A654F761
      Conserved Domains (1) summary
      PLN02714
      Location:27 → 255
      PLN02714; thiamin pyrophosphokinase

    2. NM_130040.3 → NP_566026.1  thiamine pyrophosphokinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F761, A0A7G2EI51
      Conserved Domains (1) summary
      PLN02714
      Location:27 → 253
      PLN02714; thiamin pyrophosphokinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IV16.1

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