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    Ildr2 immunoglobulin-like domain containing receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 100039795, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Ildr2provided by MGI
    Official Full Name
    immunoglobulin-like domain containing receptor 2provided by MGI
    Primary source
    MGI:MGI:1196370
    See related
    Ensembl:ENSMUSG00000040612 AllianceGenome:MGI:1196370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ll; Dbsm1; D1Ertd471e; 2810478N18Rik; 3110063L10Rik
    Summary
    Involved in negative regulation of T cell activation and regulation of RNA splicing. Acts upstream of or within several processes, including homeostasis of number of cells within a tissue; insulin secretion; and response to glucose. Located in tight junction. Is expressed in embryo; forebrain; medial ganglionic eminence; and retina. Orthologous to human ILDR2 (immunoglobulin like domain containing receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 9.1), cortex adult (RPKM 6.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ildr2 in Genome Data Viewer
    Location:
    1 H2.3; 1 73.61 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (166081630..166144405)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (166254060..166316832)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7772 Neighboring gene glycoprotein A33 transmembrane Neighboring gene STARR-seq mESC enhancer starr_02926 Neighboring gene maelstrom spermatogenic transposon silencer Neighboring gene STARR-positive B cell enhancer mm9_chr1:168290436-168290736 Neighboring gene STARR-seq mESC enhancer starr_02930 Neighboring gene STARR-positive B cell enhancer ABC_E11695 Neighboring gene transcriptional adaptor 1 Neighboring gene STARR-seq mESC enhancer starr_02931 Neighboring gene pogo transposable element with KRAB domain Neighboring gene ubiquinol-cytochrome c reductase subunit pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance. Podojil JR, et al. J Immunol, 2018 Mar 15. PMID 29431690, Free PMC Article
    2. Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2). Huetter J, et al. Cancer Immunol Res, 2020 Jul. PMID 32312711
    3. ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis. Watanabe K, et al. PLoS One, 2013. PMID 23826244, Free PMC Article
    4. ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses. Hecht I, et al. J Immunol, 2018 Mar 15. PMID 29431694, Free PMC Article
    5. ILDR2 has a negligible role in hepatic steatosis. Millings EJ, et al. PLoS One, 2018. PMID 29847571, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2).
      Title: Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2).
    2. ILDR2 as a novel negative regulator for T cells.
      Title: ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.
    3. The potential of ILDR-Fc to provide a promising therapeutic approach for the treatment of autoimmune diseases.
      Title: ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance.
    4. We conclude that ILDR2 plays a negligible role in hepatic steatosis. Rather, hepatic steatosis observed previously in Ildr2 knockdown mice was likely due to shRNA targeting of Dgka and/or other "off-target" genes.
      Title: ILDR2 has a negligible role in hepatic steatosis.
    5. manipulation of Ildr2 expression in liver affects both lipid homeostasis and ER stress pathways.
      Title: ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pancreas development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    immunoglobulin-like domain-containing receptor 2
    Names
    angulin-3
    lisch-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164528.1 → NP_001158000.1  immunoglobulin-like domain-containing receptor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001158000.1

      Status: VALIDATED

      Source sequence(s)
      AC034122
      Consensus CDS
      CCDS48431.1
      UniProtKB/Swiss-Prot
      B5TVM2, B5TVM3, B5TVM4, B5TVM5, B5TVM6, B5TVM7, B5TVM8, B5TVM9, E9Q9U5
      Related
      ENSMUSP00000107047.2, ENSMUST00000111416.7
      Conserved Domains (2) summary
      pfam05624
      Location:201 → 227
      LSR; Lipolysis stimulated receptor (LSR)
      cl11960
      Location:49 → 182
      Ig; Immunoglobulin domain

    2. NM_001357428.1 → NP_001344357.1  immunoglobulin-like domain-containing receptor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC034122
      Consensus CDS
      CCDS87913.1
      UniProtKB/TrEMBL
      A0A0A6YXV2
      Related
      ENSMUSP00000142152.2, ENSMUST00000194964.6
      Conserved Domains (1) summary
      pfam05624
      Location:201 → 227
      LSR; Lipolysis stimulated receptor (LSR)

    3. NM_001357429.1 → NP_001344358.1  immunoglobulin-like domain-containing receptor 2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC034122
      Consensus CDS
      CCDS87916.1
      UniProtKB/TrEMBL
      A0A0A6YWD2
      Related
      ENSMUSP00000141502.2, ENSMUST00000192732.6

    4. NM_001357430.1 → NP_001344359.1  immunoglobulin-like domain-containing receptor 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC034122
      Consensus CDS
      CCDS87915.1
      UniProtKB/TrEMBL
      A0A0A6YY76
      Related
      ENSMUSP00000142311.2, ENSMUST00000192638.6
      Conserved Domains (1) summary
      pfam05624
      Location:182 → 208
      LSR; Lipolysis stimulated receptor (LSR)

    5. NM_001357431.1 → NP_001344360.1  immunoglobulin-like domain-containing receptor 2 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC034122
      Consensus CDS
      CCDS87914.1
      UniProtKB/TrEMBL
      A0A0A6YVY9
      Related
      ENSMUSP00000141323.2, ENSMUST00000193860.2
      Conserved Domains (1) summary
      cl11960
      Location:132 → 181
      Ig; Immunoglobulin domain

    6. NM_001357432.1 → NP_001344361.1  immunoglobulin-like domain-containing receptor 2 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC034122
      Consensus CDS
      CCDS87912.1
      UniProtKB/TrEMBL
      A0A0A6YY19
      Related
      ENSMUSP00000142240.2, ENSMUST00000195557.6
      Conserved Domains (2) summary
      pfam05624
      Location:201 → 227
      LSR; Lipolysis stimulated receptor (LSR)
      cl11960
      Location:49 → 182
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      166081630..166144405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164352.1 → XP_036020245.1  immunoglobulin-like domain-containing receptor 2 isoform X2

      Conserved Domains (1) summary
      cl11960
      Location:51 → 181
      Ig; Immunoglobulin domain

    2. XM_011238731.3 → XP_011237033.1  immunoglobulin-like domain-containing receptor 2 isoform X3

      Conserved Domains (1) summary
      cl11960
      Location:132 → 181
      Ig; Immunoglobulin domain

    3. XM_006496594.5 → XP_006496657.1  immunoglobulin-like domain-containing receptor 2 isoform X1

      Conserved Domains (2) summary
      pfam05624
      Location:170 → 196
      LSR; Lipolysis stimulated receptor (LSR)
      cl11960
      Location:101 → 150
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5TVM2.2 GenPept UniProtKB/Swiss-Prot:B5TVM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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