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    APK APS kinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815963, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APK
    Official Full Name
    APS kinase
    Primary source
    TAIR:AT2G14750
    Locus tag
    AT2G14750
    See related
    Araport:AT2G14750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADENOSINE PHOSPHOSULFATE KINASE; ADENOSINE-5'-PHOSPHOSULFATE (APS) KINASE 1; AKN1; APK1; APS kinase; APS KINASE 1; ATAKN1; F26C24.11; F26C24_11
    Summary
    Encodes adenosine-5'-phosphosulfate kinase. Provides activated sulfate for sulfation of secondary metabolites, including the glucosinolates. Essential for pollen viability.
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    Genomic context

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    See APK in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (6313883..6316047)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene vacuolar sorting receptor 3 Neighboring gene Myb/SANT-like DNA-binding domain protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide binding site communication in Arabidopsis thaliana adenosine 5'-phosphosulfate kinase. Ravilious GE, et al. J Biol Chem, 2012 Aug 31. PMID 22810229, Free PMC Article
    2. Structural basis and evolution of redox regulation in plant adenosine-5'-phosphosulfate kinase. Ravilious GE, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22184237, Free PMC Article
    3. Molecular and catalytic properties of Arabidopsis thaliana adenylyl sulfate (APS)-kinase. Lillig CH, et al. Arch Biochem Biophys, 2001 Aug 15. PMID 11488606
    4. Adenosine-5'-phosphosulfate kinase is essential for Arabidopsis viability. Mugford SG, et al. FEBS Lett, 2010 Jan 4. PMID 19903478
    5. Disruption of adenosine-5'-phosphosulfate kinase in Arabidopsis reduces levels of sulfated secondary metabolites. Mugford SG, et al. Plant Cell, 2009 Mar. PMID 19304933, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nucleotide binding site communication in Arabidopsis thaliana adenosine 5'-phosphosulfate kinase.
      Title: Nucleotide binding site communication in Arabidopsis thaliana adenosine 5'-phosphosulfate kinase.
    2. The redox-sensitive APSK evolved after bifurcation of the sulfur assimilatory pathway in the green plant lineage.
      Title: Structural basis and evolution of redox regulation in plant adenosine-5'-phosphosulfate kinase.
    3. Results indicate that the APK1 and APK2 isoforms of adenosine 5'-phosphosulfate kinase play a major role in the synthesis of secondary sulfated metabolites and are required for normal growth rates.
      Title: Disruption of adenosine-5'-phosphosulfate kinase in Arabidopsis reduces levels of sulfated secondary metabolites.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_127039.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenylylsulfate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hydrogen sulfide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within male gamete generation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of glucosinolate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sulfate assimilation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    APS kinase
    NP_179082.1
    • APS kinase (APK); CONTAINS InterPro DOMAIN/s: Adenylylsulphate kinase, C-terminal (InterPro:IPR002891); BEST Arabidopsis thaliana protein match is: APS-kinase 2 (TAIR:AT4G39940.1); Has 5042 Blast hits to 5042 proteins in 1485 species: Archae - 54; Bacteria - 2991; Metazoa - 244; Fungi - 284; Plants - 130; Viruses - 2; Other Eukaryotes - 1337 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      6313883..6316047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127039.4 → NP_179082.1  APS kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179082.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q43295, Q8LES2
      UniProtKB/TrEMBL
      A0A178VLM3, A0A7G2E694
      Conserved Domains (1) summary
      COG0529
      Location:79 → 275
      CysC; Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q43295.1

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