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    MVP1 GDSL-like Lipase/Acylhydrolase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841841, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MVP1
    Official Full Name
    GDSL-like Lipase/Acylhydrolase superfamily protein
    Primary source
    TAIR:AT1G54030
    Locus tag
    AT1G54030
    See related
    Araport:AT1G54030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ENDOPLASMIC RETICULUM MORPHOLOGY 3; ERMO3; F15I1.11; F15I1_11; GOLD36; GOLGI DEFECTS 36; MODIFIED VACUOLE PHENOTYPE 1; NUC; NUCLEAR CAGE
    Summary
    Encodes a vacuolar protein. Mutation causes organizational defects in the endoplasmic reticulum and aberrant protein trafficking in the plant secretory pathway.
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    Genomic context

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    See MVP1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (20167597..20169684)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene miscRNA Neighboring gene epithiospecifier protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A missense mutation in the vacuolar protein GOLD36 causes organizational defects in the ER and aberrant protein trafficking in the plant secretory pathway. Marti L, et al. Plant J, 2010 Sep. PMID 20626647
    2. ERMO3/MVP1/GOLD36 is involved in a cell type-specific mechanism for maintaining ER morphology in Arabidopsis thaliana. Nakano RT, et al. PLoS One, 2012. PMID 23155454, Free PMC Article
    3. MODIFIED VACUOLE PHENOTYPE1 is an Arabidopsis myrosinase-associated protein involved in endomembrane protein trafficking. Agee AE, et al. Plant Physiol, 2010 Jan. PMID 19880612, Free PMC Article
    4. Trafficking of the myrosinase-associated protein GLL23 requires NUC/MVP1/GOLD36/ERMO3 and the p24 protein CYB. Jancowski S, et al. Plant J, 2014 Feb. PMID 24330158
    5. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NUC acts upstream of CYB in the export of GLL23 from the endoplasmic reticulum (ER).
      Title: Trafficking of the myrosinase-associated protein GLL23 requires NUC/MVP1/GOLD36/ERMO3 and the p24 protein CYB.
    2. Our results suggest that ERMO3/MVP1/GOLD36 is required for preventing ER and other organelles from abnormal aggregation and for maintaining proper ER morphology in a coordinated manner with NAI1.
      Title: ERMO3/MVP1/GOLD36 is involved in a cell type-specific mechanism for maintaining ER morphology in Arabidopsis thaliana.
    3. A missense mutation in a small endomembrane protein encoded by the gold36 locus (At1g54030)causes organizational defects in the ER and aberrant protein trafficking in the plant secretory pathway.
      Title: A missense mutation in the vacuolar protein GOLD36 causes organizational defects in the ER and aberrant protein trafficking in the plant secretory pathway.
    4. It was suggested that propose that MVP1 is a myrosinase-associated protein that functions, in part, to correctly localize the myrosinase TGG2 and prevent inappropriate glucosinolate hydrolysis that could generate cytotoxic molecules.
      Title: MODIFIED VACUOLE PHENOTYPE1 is an Arabidopsis myrosinase-associated protein involved in endomembrane protein trafficking.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104280.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein exit from endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ER body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GDSL-like Lipase/Acylhydrolase superfamily protein
    NP_175805.1
    • MODIFIED VACUOLE PHENOTYPE 1 (MVP1); FUNCTIONS IN: lipase activity, hydrolase activity, acting on ester bonds, carboxylesterase activity; INVOLVED IN: intracellular protein transport; LOCATED IN: plant-type vacuole membrane, endoplasmic reticulum, vacuole, ER body; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Lipase, GDSL (InterPro:IPR001087); BEST Arabidopsis thaliana protein match is: GDSL-like Lipase/Acylhydrolase superfamily protein (TAIR:AT1G54010.1); Has 3257 Blast hits to 3227 proteins in 154 species: Archae - 0; Bacteria - 207; Metazoa - 0; Fungi - 19; Plants - 3013; Viruses - 0; Other Eukaryotes - 18 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20167597..20169684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333627.1 → NP_001323162.1  GDSL-like Lipase/Acylhydrolase superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AW84

    2. NM_104280.4 → NP_175805.1  GDSL-like Lipase/Acylhydrolase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175805.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7XA74, Q8LA76, Q9SYF9
      UniProtKB/TrEMBL
      A0A178W8Q3, A0A654EI97
      Conserved Domains (1) summary
      cd01837
      Location:52 → 348
      SGNH_plant_lipase_like; SGNH_plant_lipase_like, a plant specific subfamily of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7XA74.1

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