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    VLN4 villin 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829139, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VLN4
    Official Full Name
    villin 4
    Primary source
    TAIR:AT4G30160
    Locus tag
    AT4G30160
    See related
    Araport:AT4G30160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATVLN4; F9N11.10; F9N11_10; villin 4
    Summary
    Encodes a major actin filament bundling protein that is involved in root hair growth through regulating actin organization in a Ca2+-dependent manner.
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    Genomic context

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    See VLN4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    25
    Sequence:
    Chromosome: 4; NC_003075.7 (14753232..14760236)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene DUF630 family protein (DUF630 and DUF632) Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene Urb2/Npa2 family protein Neighboring gene Peroxidase family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Auxin Transport Inhibitor Targets Villin-Mediated Actin Dynamics to Regulate Polar Auxin Transport. Zou M, et al. Plant Physiol, 2019 Sep. PMID 31311831, Free PMC Article
    2. The universal bundling activity of AtVLN4 in diffusely growing cells. Du F, et al. Plant Signal Behav, 2011 Sep. PMID 22019634, Free PMC Article
    3. Arabidopsis VILLIN4 is involved in root hair growth through regulating actin organization in a Ca2+-dependent manner. Zhang Y, et al. New Phytol, 2011 May. PMID 21275995
    4. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787
    5. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An Auxin Transport Inhibitor Targets Villin-Mediated Actin Dynamics to Regulate Polar Auxin Transport.
      Title: An Auxin Transport Inhibitor Targets Villin-Mediated Actin Dynamics to Regulate Polar Auxin Transport.
    2. Results demonstrate that AtVLN4 has a universal actin bundling activity in diffusely growing cells just like that in the tip growing cell, root hairs.
      Title: The universal bundling activity of AtVLN4 in diffusely growing cells.
    3. AtVLN4 is involved in root hair growth through regulating actin organization in a Ca(2+)-dependent manner.
      Title: Arabidopsis VILLIN4 is involved in root hair growth through regulating actin organization in a Ca2+-dependent manner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203940.1
    NM_001342000.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin crosslink formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament severing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cytoplasmic streaming IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in intracellular anatomical structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    villin 4
    NP_001190869.1
    • villin 4 (VLN4); FUNCTIONS IN: actin binding; INVOLVED IN: cytoskeleton organization; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Gelsolin (InterPro:IPR007122), Villin headpiece (InterPro:IPR003128), Gelsolin domain (InterPro:IPR007123); BEST Arabidopsis thaliana protein match is: villin, putative (TAIR:AT5G57320.1).
    NP_194745.1
    • villin 4 (VLN4); FUNCTIONS IN: actin binding; INVOLVED IN: cytoskeleton organization; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Gelsolin (InterPro:IPR007122), Villin headpiece (InterPro:IPR003128), Gelsolin domain (InterPro:IPR007123); BEST Arabidopsis thaliana protein match is: villin, putative (TAIR:AT5G57320.1); Has 3425 Blast hits to 2326 proteins in 232 species: Archae - 0; Bacteria - 22; Metazoa - 2546; Fungi - 193; Plants - 266; Viruses - 0; Other Eukaryotes - 398 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14753232..14760236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119162.5 → NP_194745.1  villin 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194745.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JPJ2, O65570, Q541Y5, Q9SZW9
      UniProtKB/TrEMBL
      A0A178V1L5, A0A5S9XXM3, A0A654FUM3
      Conserved Domains (8) summary
      cd11288
      Location:517 → 608
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:139 → 217
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:12 → 124
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:621 → 720
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:253 → 343
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:386 → 486
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      PHA03247
      Location:741 → 869
      PHA03247; large tegument protein UL36; Provisional
      pfam02209
      Location:939 → 973
      VHP; Villin headpiece domain

    2. NM_001341999.1 → NP_001329918.1  villin 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JPJ2, O65570, Q541Y5, Q9SZW9
      UniProtKB/TrEMBL
      A0A178V1L5, A0A5S9XXM3, A0A654FUM3
      Conserved Domains (8) summary
      cd11288
      Location:517 → 608
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:139 → 217
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:12 → 124
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:621 → 720
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:253 → 343
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:386 → 486
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      PHA03247
      Location:741 → 869
      PHA03247; large tegument protein UL36; Provisional
      pfam02209
      Location:939 → 973
      VHP; Villin headpiece domain

    3. NM_001203940.1 → NP_001190869.1  villin 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FUM3
      Conserved Domains (7) summary
      cd11288
      Location:517 → 608
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:139 → 217
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:12 → 124
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:621 → 729
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:253 → 343
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:386 → 486
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:949 → 983
      VHP; Villin headpiece domain

    4. NM_001342000.1 → NP_001329917.1  villin 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JPJ2, O65570, Q541Y5, Q9SZW9
      UniProtKB/TrEMBL
      A0A178V1L5, A0A5S9XXM3, A0A654FUM3
      Conserved Domains (8) summary
      cd11288
      Location:517 → 608
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:139 → 217
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:12 → 124
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:621 → 720
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:253 → 343
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:386 → 486
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      PHA03247
      Location:741 → 869
      PHA03247; large tegument protein UL36; Provisional
      pfam02209
      Location:939 → 973
      VHP; Villin headpiece domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65570.1

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