Man2c1 mannosidase, alpha, class 2C, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Man2c1provided by MGI
Official Full Name: mannosidase, alpha, class 2C, member 1provided by MGI
Primary source: MGI:MGI:1920994
See related: Ensembl:ENSMUSG00000032295 AllianceGenome:MGI:1920994
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110025H24Rik
Summary: Enables alpha-mannosidase activity. Involved in oligosaccharide catabolic process. Is active in cytosol. Human ortholog(s) of this gene implicated in congenital disorder of deglycosylation 2. Orthologous to human MAN2C1 (mannosidase alpha class 2C member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 30.4), ovary adult (RPKM 29.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 30.89 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (57037953..57049497)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (57130675..57142213)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings confirm the key role played by Man2c1 in the catabolism of free oligosaccharides.
Title: Accumulation of free oligosaccharides and tissue damage in cytosolic α-mannosidase (Man2c1)-deficient mice.
Comparison of the mouse genomic sequence with the cDNA sequence revealed the presence of 25 introns within the cytosolic alpha-mannosidase gene. The gene spans 11.5 kb from the major transcription initiation site to the RNA cleavage site.
Title: Cloning and expression of mouse cytosolic alpha-mannosidase (Man2c1).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI851351 (e-PCR)
- UniSTS:165634

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-mannosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-mannosidase activity	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mannose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-mannosidase 2C1

Names: alpha-D-mannoside mannohydrolase; cytosolic alpha-D-mannosidase; neutral/cytosolic alpha-mannosidase

NP_082912.1

EC 3.2.1.24

XP_006511557.1

EC 3.2.1.24

XP_006511562.1

EC 3.2.1.24

XP_017169108.1

EC 3.2.1.24

XP_030100511.1

EC 3.2.1.24

XP_030100512.1

EC 3.2.1.24

XP_030100514.1

EC 3.2.1.24

XP_030100515.1

EC 3.2.1.24

XP_030100517.1

EC 3.2.1.24

XP_036011231.1

EC 3.2.1.24

XP_036011232.1

EC 3.2.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028636.2 → NP_082912.1 alpha-mannosidase 2C1

See identical proteins and their annotated locations for NP_082912.1

Status: PROVISIONAL

Source sequence(s)

AC132406

Consensus CDS

CCDS40646.1

UniProtKB/Swiss-Prot

Q3ZCX9, Q91W89

UniProtKB/TrEMBL

Q8BWY6

Related

ENSMUSP00000125478.2, ENSMUST00000160147.8

Conserved Domains (4) summary

cd10813
Location:251 → 502

GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)

smart00872
Location:517 → 595

Alpha-mann_mid; Alpha mannosidase, middle domain

COG0383
Location:39 → 1034

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

pfam07748
Location:621 → 1030

Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

57037953..57049497

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313619.3 → XP_017169108.1 alpha-mannosidase 2C1 isoform X2

UniProtKB/TrEMBL

A0A1S6GWG9

Conserved Domains (2) summary

cd10813
Location:277 → 569

GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)

COG0383
Location:65 → 1066

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
XM_006511494.5 → XP_006511557.1 alpha-mannosidase 2C1 isoform X1

UniProtKB/TrEMBL

A0A1S6GWG9

Conserved Domains (2) summary

cd10813
Location:277 → 569

GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)

COG0383
Location:65 → 1101

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
XM_006511499.5 → XP_006511562.1 alpha-mannosidase 2C1 isoform X10

UniProtKB/TrEMBL

A0A1S6GWG9

Conserved Domains (2) summary

cd10813
Location:277 → 528

GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)

COG0383
Location:65 → 1071

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
XM_030244651.2 → XP_030100511.1 alpha-mannosidase 2C1 isoform X3

UniProtKB/TrEMBL

A0A1S6GWG9

Conserved Domains (2) summary

cd10813
Location:277 → 528

GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)

COG0383
Location:65 → 1025

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
XM_030244655.1 → XP_030100515.1 alpha-mannosidase 2C1 isoform X8

UniProtKB/TrEMBL

Q8BWY6

Conserved Domains (2) summary

cd10813
Location:92 → 343

GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)

COG0383
Location:93 → 875

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
XM_030244652.2 → XP_030100512.1 alpha-mannosidase 2C1 isoform X4

UniProtKB/TrEMBL

Q8BWY6

Conserved Domains (2) summary

cd10813
Location:146 → 438

GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)

COG0383
Location:147 → 970

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
XM_030244657.2 → XP_030100517.1 alpha-mannosidase 2C1 isoform X9

Conserved Domains (2) summary

COG0383
Location:21 → 792

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

cl15692
Location:21 → 260

CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily
XM_036155338.1 → XP_036011231.1 alpha-mannosidase 2C1 isoform X5

UniProtKB/TrEMBL

Q8BWY6

Conserved Domains (2) summary

cd10813
Location:146 → 397

GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)

COG0383
Location:147 → 929

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
XM_036155339.1 → XP_036011232.1 alpha-mannosidase 2C1 isoform X7

UniProtKB/TrEMBL

Q8BWY6

Conserved Domains (2) summary

cd10813
Location:146 → 397

GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)

COG0383
Location:147 → 894

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
XM_030244654.2 → XP_030100514.1 alpha-mannosidase 2C1 isoform X6

UniProtKB/TrEMBL

Q8BWY6

Conserved Domains (2) summary

cd10813
Location:92 → 384

GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)

COG0383
Location:93 → 916

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]