AMT1;3 ammonium transporter 1;3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AMT1;3
Official Full Name: ammonium transporter 1;3
Primary source: TAIR:AT3G24300
Locus tag: AT3G24300
See related: Araport:AT3G24300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ammonium transporter 1;3; AMMONIUM TRANSPORTER 1;3; ATAMT1;3
Summary: Encodes a plasma membrane localized ammonium transporter.
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Genomic context

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See AMT1;3 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 1

Sequence:: Chromosome: 3; NC_003074.8 (8805519..8807460, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Feedback inhibition of AMT1 NH4(+)-transporters mediated by CIPK15 kinase.
Title: Feedback inhibition of AMT1 NH(4)(+)-transporters mediated by CIPK15 kinase.
Under ammonium resupply rapid phosphorylation of a Thr residue (T464) in the conserved part of the CTR effectively inhibited AtAMT1;3-dependent NH4+ uptake. Moreover, phosphorylation of Thr (T494), one of three phosphorylation sites in the non-conserved part of the CTR, moderately decreased the NH4+ transport activity of AtAMT1;3.
Title: Ammonium and nitrate regulate NH4+ uptake activity of Arabidopsis ammonium transporter AtAMT1;3 via phosphorylation at multiple C-terminal sites.
AMT1;1 and AMT1;3 form homo- and hetero-oligomers at the plasma membrane in plants.
Title: Allosteric regulation of transport activity by heterotrimerization of Arabidopsis ammonium transporter complexes in vivo.
Results show that the clustering and endocytosis of AMT1;3 indicating an effective mechanism by which plant cells can avoid accumulation of toxic levels of ammonium by eliminating active AMT1;3 from the plasma membrane.
Title: Single-particle analysis reveals shutoff control of the Arabidopsis ammonium transporter AMT1;3 by clustering and internalization.
These results show that ammonium is complementary to nitrate in shaping lateral root development and that stimulation of lateral root branching by ammonium occurs in an AMT1;3-dependent manner.
Title: Ammonium triggers lateral root branching in Arabidopsis in an AMMONIUM TRANSPORTER1;3-dependent manner.
Thus, AMT1 phosphorylation appears to function in a feedback loop restricting ammonium uptake. T
Title: Feedback inhibition of ammonium uptake by a phospho-dependent allosteric mechanism in Arabidopsis.
The results of this study suggest an additive contribution of AMT1;1 and AMT1;3 to the overall ammonium uptake capacity in Arabidopsis roots under nitrogen-deficiency conditions.
Title: Additive contribution of AMT1;1 and AMT1;3 to high-affinity ammonium uptake across the plasma membrane of nitrogen-deficient Arabidopsis roots.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_113336.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ammonium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ammonium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within lateral root branching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral root formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ammonium transporter 1;3

NP_189073.1

ammonium transporter 1;3 (AMT1;3); CONTAINS InterPro DOMAIN/s: Ammonium transporter (InterPro:IPR001905), Ammonium transporter, conserved site (InterPro:IPR018047); BEST Arabidopsis thaliana protein match is: ammonium transporter 1;5 (TAIR:AT3G24290.1); Has 11505 Blast hits to 11486 proteins in 2067 species: Archae - 224; Bacteria - 4696; Metazoa - 434; Fungi - 433; Plants - 469; Viruses - 0; Other Eukaryotes - 5249 (source: NCBI BLink).