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    Tcte1 t-complex-associated testis expressed 1 [ Mus musculus (house mouse) ]

    Gene ID: 21645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcte1provided by MGI
    Official Full Name
    t-complex-associated testis expressed 1provided by MGI
    Primary source
    MGI:MGI:98640
    See related
    Ensembl:ENSMUSG00000023949 AllianceGenome:MGI:98640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcte-1; D17Sil1
    Summary
    Involved in flagellated sperm motility. Located in sperm flagellum. Used to study male infertility. Orthologous to human TCTE1 (t-complex-associated-testis-expressed 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 114.1), cerebellum adult (RPKM 9.0) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tcte1 in Genome Data Viewer
    Location:
    17 B3; 17 22.54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45834360..45853605)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45523434..45542679)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated, serine-rich 1 Neighboring gene STARR-seq mESC enhancer starr_42624 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45625569-45626099 Neighboring gene STARR-seq mESC enhancer starr_42626 Neighboring gene STARR-positive B cell enhancer ABC_E4215 Neighboring gene STARR-positive B cell enhancer ABC_E9052 Neighboring gene alanyl-tRNA synthetase 2, mitochondrial Neighboring gene transmembrane protein 151B Neighboring gene STARR-positive B cell enhancer ABC_E7533 Neighboring gene STARR-positive B cell enhancer ABC_E961 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45695258-45695367 Neighboring gene STARR-positive B cell enhancer ABC_E10954 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon Neighboring gene solute carrier family 35, member B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effects of Tcte1 knockout on energy chain transportation and spermatogenesis: implications for male infertility. Olszewska M, et al. Hum Reprod Open, 2024. PMID 38650655, Free PMC Article
    2. Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6. Bibbins KB, et al. Genomics, 1989 Jul. PMID 2767684
    3. Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. Morohoshi A, et al. PLoS Genet, 2020 Jan. PMID 31961863, Free PMC Article
    4. TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Castaneda JM, et al. Proc Natl Acad Sci U S A, 2017 Jul 3. PMID 28630322, Free PMC Article
    5. Identification of a testis-specific gene from the mouse t-complex next to a CpG-rich island. Rappold GA, et al. EMBO J, 1987 Jul. PMID 3653077, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mouse TCTE1 is testis-enriched in its expression, with its mRNA appearing in early round spermatids and protein localized to the flagellum
      Title: TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein regulatory complex subunit 5
    Names
    T-complex-associated testis-expressed protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013688.3 → NP_038716.2  dynein regulatory complex subunit 5

      See identical proteins and their annotated locations for NP_038716.2

      Status: VALIDATED

      Source sequence(s)
      AC163677
      Consensus CDS
      CCDS37629.1
      UniProtKB/Swiss-Prot
      A6H639, Q62294
      Related
      ENSMUSP00000109175.2, ENSMUST00000113547.2
      Conserved Domains (3) summary
      cd00116
      Location:177 → 487
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:307 → 333
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:238 → 278
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      45834360..45853605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6H639.1 GenPept UniProtKB/Swiss-Prot:A6H639

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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