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    GAPCP-2 glyceraldehyde-3-phosphate dehydrogenase of plastid 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838199, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GAPCP-2
    Official Full Name
    glyceraldehyde-3-phosphate dehydrogenase of plastid 2
    Primary source
    TAIR:AT1G16300
    Locus tag
    AT1G16300
    See related
    Araport:AT1G16300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F3O9.10; F3O9_10; glyceraldehyde-3-phosphate dehydrogenase of plastid 2
    Summary
    Encodes one of the chloroplast/plastid localized GAPDH isoforms (GAPCp1/At1g79530 and GAPCp2/At1g16300). gapcp double mutants display a drastic phenotype of arrested root development, dwarfism and sterility. GAPCps are important for the synthesis of serine in roots.
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    Genomic context

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    See GAPCP-2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (5574257..5577622)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene kinase superfamily with octicosapeptide/Phox/Bem1p domain-containing protein Neighboring gene RNA helicase 36 Neighboring gene transglycosylase Neighboring gene Cation efflux family protein Neighboring gene plant/protein (DUF2358)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis plants deficient in plastidial glyceraldehyde-3-phosphate dehydrogenase show alterations in abscisic acid (ABA) signal transduction: interaction between ABA and primary metabolism. Muñoz-Bertomeu J, et al. J Exp Bot, 2011 Jan. PMID 21068209, Free PMC Article
    2. Plastidial glyceraldehyde-3-phosphate dehydrogenase deficiency leads to altered root development and affects the sugar and amino acid balance in Arabidopsis. Muñoz-Bertomeu J, et al. Plant Physiol, 2009 Oct. PMID 19675149, Free PMC Article
    3. Overexpression of the triose phosphate translocator (TPT) complements the abnormal metabolism and development of plastidial glycolytic glyceraldehyde-3-phosphate dehydrogenase mutants. Flores-Tornero M, et al. Plant J, 2017 Mar. PMID 27984670
    4. Co-ordinated gene expression of photosynthetic glyceraldehyde-3-phosphate dehydrogenase, phosphoribulokinase, and CP12 in Arabidopsis thaliana. Marri L, et al. J Exp Bot, 2005 Jan. PMID 15533878
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that the main function of gapcp2 is to supply 3-PGA for anabolic pathways in plastids of heterotrophic cells and suggest that the plastidial glycolysis may contribute to fatty acid biosynthesis in seeds.
      Title: Overexpression of the triose phosphate translocator (TPT) complements the abnormal metabolism and development of plastidial glycolytic glyceraldehyde-3-phosphate dehydrogenase mutants.
    2. Mutants deficient in plastidial gapcp1 and gapcp2 are abscisic acid insensitive in growth.
      Title: Arabidopsis plants deficient in plastidial glyceraldehyde-3-phosphate dehydrogenase show alterations in abscisic acid (ABA) signal transduction: interaction between ABA and primary metabolism.
    3. Two Arabidopsis thaliana chloroplast/plastid-localized GAPDH isoforms (GAPCp1 and GAPCp2), were identified.
      Title: Plastidial glyceraldehyde-3-phosphate dehydrogenase deficiency leads to altered root development and affects the sugar and amino acid balance in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_101496.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular amino acid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within primary root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glyceraldehyde-3-phosphate dehydrogenase of plastid 2
    NP_173080.1
    • glyceraldehyde-3-phosphate dehydrogenase of plastid 2 (GAPCP-2); CONTAINS InterPro DOMAIN/s: Glyceraldehyde 3-phosphate dehydrogenase subfamily (InterPro:IPR000173), Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain (InterPro:IPR020829), Glyceraldehyde-3-phosphate dehydrogenase, type I (InterPro:IPR006424), Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain, subgroup (InterPro:IPR020832), Glyceraldehyde 3-phosphate dehydrogenase, active site (InterPro:IPR020830), Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain (InterPro:IPR020828); BEST Arabidopsis thaliana protein match is: glyceraldehyde-3-phosphate dehydrogenase of plastid 1 (TAIR:AT1G79530.1); Has 25238 Blast hits to 25227 proteins in 6343 species: Archae - 51; Bacteria - 10898; Metazoa - 2382; Fungi - 2852; Plants - 3834; Viruses - 0; Other Eukaryotes - 5221 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5574257..5577622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101496.3 → NP_173080.1  glyceraldehyde-3-phosphate dehydrogenase of plastid 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173080.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5E924, Q84WR0, Q8L8W7, Q9SA29
      UniProtKB/TrEMBL
      A0A5S9UMZ3, A0A654EL52, A0A7G2DU31
      Conserved Domains (1) summary
      PLN02272
      Location:1 → 420
      PLN02272; glyceraldehyde-3-phosphate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5E924.1

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