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    Luzp1 leucine zipper protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 269593, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Luzp1provided by MGI
    Official Full Name
    leucine zipper protein 1provided by MGI
    Primary source
    MGI:MGI:107629
    See related
    Ensembl:ENSMUSG00000001089 AllianceGenome:MGI:107629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Luzp; mFLJ00226; 2700072H04Rik
    Summary
    Enables microtubule binding activity. Involved in apical constriction; negative regulation of cilium assembly; and regulation of protein complex stability. Acts upstream of or within artery development; neural fold bending; and ventricular septum development. Located in nucleus and tight junction. Part of CERF complex. Is expressed in several structures, including alimentary system; brain; pharyngo-tympanic tube; skin; and submandibular gland primordium. Orthologous to human LUZP1 (leucine zipper protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.4), cerebellum adult (RPKM 11.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Luzp1 in Genome Data Viewer
    Location:
    4 D3; 4 68.8 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136189892..136282036)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136462609..136554725)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31295 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1D Neighboring gene lysine (K)-specific demethylase 1A Neighboring gene STARR-positive B cell enhancer ABC_E6238 Neighboring gene STARR-positive B cell enhancer mm9_chr4:136177240-136177540 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene testis expressed 46 Neighboring gene lactamase, beta-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction. Yano T, et al. EMBO J, 2021 Jan 15. PMID 33346378, Free PMC Article
    2. Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling. Fan D, et al. J Adv Res, 2024 Sep. PMID 37806546, Free PMC Article
    3. Restricted expression of LUZP in neural lineage cells: a study in embryonic stem cells. Lee MW, et al. J Biomed Sci, 2001 Nov-Dec. PMID 11702014
    4. LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome. Bozal-Basterra L, et al. Elife, 2020 Jun 18. PMID 32553112, Free PMC Article
    5. LUZP deficiency affects neural tube closure during brain development. Hsu CY, et al. Biochem Biophys Res Commun, 2008 Nov 21. PMID 18801334

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling.
      Title: Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling.
    2. Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.
      Title: Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.
    3. A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction.
      Title: A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction.
    4. These findings assign a novel function of LUZP in the embryonic development of brain.
      Title: LUZP deficiency affects neural tube closure during brain development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC169408, MGC169410

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apical constriction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within artery development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in contractile ring contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neural fold bending IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein complex stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CERF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome, centromeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle midzone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in stress fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine zipper protein 1
    Names
    leucine zipper motif-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024452.2 → NP_077772.2  leucine zipper protein 1

      See identical proteins and their annotated locations for NP_077772.2

      Status: VALIDATED

      Source sequence(s)
      AK139583, AL671173
      Consensus CDS
      CCDS38923.1
      UniProtKB/Swiss-Prot
      A3KG96, Q3UV18, Q7TS71, Q8BQW1, Q8R4U7, Q99NG3, Q9CSL6
      UniProtKB/TrEMBL
      B2RQ68
      Related
      ENSMUSP00000130758.2, ENSMUST00000170102.8
      Conserved Domains (1) summary
      COG1196
      Location:19 → 354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      136189892..136282036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253587.2 → XP_030109447.1  leucine zipper protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A3KG96, Q3UV18, Q7TS71, Q8BQW1, Q8R4U7, Q99NG3, Q9CSL6
      UniProtKB/TrEMBL
      B2RQ68
      Conserved Domains (1) summary
      COG1196
      Location:19 → 354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_006538921.3 → XP_006538984.1  leucine zipper protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006538984.1

      UniProtKB/Swiss-Prot
      A3KG96, Q3UV18, Q7TS71, Q8BQW1, Q8R4U7, Q99NG3, Q9CSL6
      UniProtKB/TrEMBL
      B2RQ68
      Related
      ENSMUSP00000101475.3, ENSMUST00000105849.9
      Conserved Domains (1) summary
      COG1196
      Location:19 → 354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_030253588.1 → XP_030109448.1  leucine zipper protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RQ68
      Conserved Domains (1) summary
      COG1196
      Location:19 → 354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_390755.2 RNA Sequence

    2. XR_390753.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4U7.2 GenPept UniProtKB/Swiss-Prot:Q8R4U7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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