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    FC2 LAMMER-type protein kinase AFC2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828576, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FC2
    Official Full Name
    LAMMER-type protein kinase AFC2
    Primary source
    TAIR:AT4G24740
    Locus tag
    AT4G24740
    See related
    Araport:AT4G24740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AFC2; AME1; CLK/STY (LAMMER-TYPE) PROTEIN KINASE; F22K18.60; F22K18_60; FUS3-complementing gene 2
    Summary
    a LAMMER-type protein kinase that co-precipitates with serine/arginine-rich (SR) proteins in vitro, interaction modulated by phosphorylation of the proteins.
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    Genomic context

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    See FC2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Sequence:
    Chromosome: 4; NC_003075.7 (12754489..12757866, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene high-affinity nitrate transporter-like protein Neighboring gene manganese-dependent ADP-ribose/CDP-alcohol diphosphatase-like protein Neighboring gene Rhodanese/Cell cycle control phosphatase superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An SC35-like protein and a novel serine/arginine-rich protein interact with Arabidopsis U1-70K protein. Golovkin M, et al. J Biol Chem, 1999 Dec 17. PMID 10593939
    2. Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system. Nemoto K, et al. Phytochemistry, 2011 Jul. PMID 21477822
    3. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341698.1
    NM_001341699.1
    NM_001341700.1
    NM_001341701.1
    NM_001341702.1
    NM_001341703.1
    NM_001341704.1
    NM_001341705.1
    NM_118607.3
    NM_202881.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity HDA PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    LAMMER-type protein kinase AFC2
    NP_194205.1
    • FUS3-complementing gene 2 (FC2); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: FUS3-complementing gene 1 (TAIR:AT3G53570.4); Has 78986 Blast hits to 77771 proteins in 2339 species: Archae - 44; Bacteria - 6536; Metazoa - 32511; Fungi - 11289; Plants - 12892; Viruses - 291; Other Eukaryotes - 15423 (source: NCBI BLink).
    NP_974610.1
    • FUS3-complementing gene 2 (FC2); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: FUS3-complementing gene 1 (TAIR:AT3G53570.4); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12754489..12757866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202881.2 → NP_974610.1  LAMMER-type protein kinase AFC2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JR16
      Conserved Domains (1) summary
      cd14134
      Location:1 → 320
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

    2. NM_118607.3 → NP_194205.1  LAMMER-type protein kinase AFC2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194205.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51567
      UniProtKB/TrEMBL
      A0A654FSF7, Q1EBU3
      Conserved Domains (1) summary
      cd14134
      Location:85 → 423
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

    3. NM_001341699.1 → NP_001329107.1  LAMMER-type protein kinase AFC2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6Q2
      Conserved Domains (1) summary
      cd14134
      Location:85 → 346
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

    4. NM_001341700.1 → NP_001329103.1  LAMMER-type protein kinase AFC2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UY90, A0A1P8B6Q5

    5. NM_001341703.1 → NP_001329106.1  LAMMER-type protein kinase AFC2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6Q0

    6. NM_001341705.1 → NP_001329109.1  LAMMER-type protein kinase AFC2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JR16
      Conserved Domains (1) summary
      cd14134
      Location:1 → 320
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

    7. NM_001341704.1 → NP_001329108.1  LAMMER-type protein kinase AFC2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6P6

    8. NM_001341702.1 → NP_001329105.1  LAMMER-type protein kinase AFC2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JR16
      Conserved Domains (1) summary
      cd14134
      Location:1 → 320
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

    9. NM_001341701.1 → NP_001329104.1  LAMMER-type protein kinase AFC2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6P5

    10. NM_001341698.1 → NP_001329102.1  LAMMER-type protein kinase AFC2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6P6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51567.1

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