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    SK 11 shaggy-related kinase 11 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832733, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SK 11
    Official Full Name
    shaggy-related kinase 11
    Primary source
    TAIR:AT5G26751
    Locus tag
    AT5G26751
    See related
    Araport:AT5G26751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis GSK alpha; ARABIDOPSIS THALIANA SHAGGY-RELATED KINASE 11; ASKalpha; ASKALPHA; ATSK11; F2P16.21; F2P16_21; shaggy-related kinase 11
    Summary
    encodes a SHAGGY-related kinase involved in meristem organization. It regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase 6.
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    Genomic context

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    See SK 11 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (9399377..9402476, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene AGAMOUS-like-34 Neighboring gene C2H2 and C2HC zinc fingers superfamily protein Neighboring gene RNA polymerase II subunit B1 CTD phosphatase RPAP2-like protein Neighboring gene myosin heavy chain, cardiac protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtSK11 and AtSK12 Mediate the Mild Osmotic Stress-Induced Root Growth Response in Arabidopsis. Dong L, et al. Int J Mol Sci, 2020 Jun 2. PMID 32498390, Free PMC Article
    2. Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis. Dal Santo S, et al. Plant Cell, 2012 Aug. PMID 22885737, Free PMC Article
    3. Arabidopsis thaliana SHAGGY-related protein kinases (AtSK11 and 12) function in perianth and gynoecium development. Dornelas MC, et al. Plant J, 2000 Mar. PMID 10758494
    4. Arabidopsis homologs of the shaggy and GSK-3 protein kinases: molecular cloning and functional expression in Escherichia coli. Bianchi MW, et al. Mol Gen Genet, 1994 Feb. PMID 7509023
    5. The Arabidopsis SHAGGY-related protein kinase (ASK) gene family: structure, organization and evolution. Dornelas MC, et al. Gene, 1998 Jun 8. PMID 9611268

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtSK11 and AtSK12 Mediate the Mild Osmotic Stress-Induced Root Growth Response in Arabidopsis.
      Title: AtSK11 and AtSK12 Mediate the Mild Osmotic Stress-Induced Root Growth Response in Arabidopsis.
    2. ASKalpha is activated by high salinity stress, and phosphorylates and activates G6PD6.
      Title: Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis.
    3. In vivo co-immunoprecipitation with ZTL into an SCF complex.
      Title: Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_122557.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    shaggy-related kinase 11
    NP_568486.1
    • shaggy-related kinase 11 (SK 11); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity; INVOLVED IN: meristem structural organization, phosphorylation; LOCATED IN: cytosol; EXPRESSED IN: inflorescence meristem, whole plant, cultured cell; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT3G05840.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9399377..9402476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122557.3 → NP_568486.1  shaggy-related kinase 11 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568486.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04625, O23151, P43288, Q93VJ5
      UniProtKB/TrEMBL
      A0A178UN70, A0A178VKL8, A0A5S9XAK4, A0A5S9Y7U3
      Conserved Domains (1) summary
      cd14137
      Location:64 → 356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43288.3

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