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    XDH2 xanthine dehydrogenase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829642, updated on 18-Sep-2024

    Summary

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    Official Symbol
    XDH2
    Official Full Name
    xanthine dehydrogenase 2
    Primary source
    TAIR:AT4G34900
    Locus tag
    AT4G34900
    See related
    Araport:AT4G34900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. THALIANA XANTHINE DEHYDROGENASE 2; A. THALIANA XANTHINE DEHYDROGENASE 2; ATXDH2; F11I11.140; F11I11_140; xanthine dehydrogenase 2; xanthine dehydrogenase 2
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    Genomic context

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    See XDH2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Sequence:
    Chromosome: 4; NC_003075.7 (16625517..16631370, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene xanthine dehydrogenase 1 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene PLC-like phosphodiesterases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RNAi-mediated silencing of xanthine dehydrogenase impairs growth and fertility and accelerates leaf senescence in transgenic Arabidopsis plants. Nakagawa A, et al. Plant Cell Physiol, 2007 Oct. PMID 17872919
    2. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA interference was used to generate transgenic lines of this species in which AtXDH1 and AtXDH2, the two paralogous genes for XDH in this plant, were silenced simultaneously.
      Title: The RNAi-mediated silencing of xanthine dehydrogenase impairs growth and fertility and accelerates leaf senescence in transgenic Arabidopsis plants.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001342311.1
    NM_119656.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xanthine dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in xanthine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    xanthine dehydrogenase 2
    NP_195216.2
    • xanthine dehydrogenase 2 (XDH2); FUNCTIONS IN: in 8 functions; INVOLVED IN: oxidation reduction, allantoin biosynthetic process; LOCATED IN: cellular_component unknown; CONTAINS InterPro DOMAIN/s: Aldehyde oxidase/xanthine dehydrogenase (InterPro:IPR016208), Ferredoxin (InterPro:IPR001041), Molybdopterin dehydrogenase, FAD-binding (InterPro:IPR002346), Beta-grasp fold, ferredoxin-type (InterPro:IPR012675), FAD-binding, type 2, subdomain 1 (InterPro:IPR016167), [2Fe-2S]-binding (InterPro:IPR002888), FAD-binding, type 2 (InterPro:IPR016166), CO dehydrogenase flavoprotein, C-terminal (InterPro:IPR005107), 2Fe-2S ferredoxin, iron-sulphur binding site (InterPro:IPR006058), CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 (InterPro:IPR016169), Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead (InterPro:IPR000674), Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding (InterPro:IPR008274); BEST Arabidopsis thaliana protein match is: xanthine dehydrogenase 1 (TAIR:AT4G34890.1); Has 21587 Blast hits to 20745 proteins in 1345 species: Archae - 453; Bacteria - 12993; Metazoa - 1073; Fungi - 109; Plants - 266; Viruses - 0; Other Eukaryotes - 6693 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16625517..16631370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342310.1 → NP_001329029.1  xanthine dehydrogenase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6H0, A0A7G2F894

    2. NM_119656.3 → NP_195216.2  xanthine dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195216.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JLI5, Q6R2R5, Q9SW45
      UniProtKB/TrEMBL
      A0A178UTT6, A0A654FVX4
      Conserved Domains (6) summary
      smart01008
      Location:604 → 711
      Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
      PLN02906
      Location:26 → 1344
      PLN02906; xanthine dehydrogenase
      pfam00941
      Location:252 → 431
      FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
      pfam01799
      Location:90 → 162
      Fer2_2; [2Fe-2S] binding domain
      pfam02738
      Location:730 → 1264
      Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
      pfam03450
      Location:441 → 545
      CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

    3. NM_001342311.1 → NP_001329028.1  xanthine dehydrogenase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6H2, A0A7G2FA12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JLI5.1

    Gene LinkOut

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