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    APR1 APS reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825793, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APR1
    Official Full Name
    APS reductase 1
    Primary source
    TAIR:AT4G04610
    Locus tag
    AT4G04610
    See related
    Araport:AT4G04610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE REDUCTASE; APR; APS REDUCTASE; APS reductase 1; ATAPR1; F4H6.13; F4H6_13; PAPS REDUCTASE HOMOLOG 19; PRH19
    Summary
    Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily. This protein also belongs to the adenosine 5'-phosphosulfate reductase-like (APRL) group.
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    Genomic context

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    See APR1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (2324878..2327064)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Myb-like DNA-binding domain protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-like superfamily protein Neighboring gene senescence regulator (Protein of unknown function, DUF584)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenosine 5' phosphosulfate reductase and sulfite oxidase regulate sulfite-induced water loss in Arabidopsis. Bekturova A, et al. J Exp Bot, 2021 Sep 30. PMID 34107028
    2. Crystallization of the C-terminal redox domain of the sulfur-assimilatory enzyme APR1 from Arabidopsis thaliana. Chen FF, et al. Acta Crystallogr F Struct Biol Commun, 2014 Sep. PMID 25195893, Free PMC Article
    3. Complex signaling network in regulation of adenosine 5'-phosphosulfate reductase by salt stress in Arabidopsis roots. Koprivova A, et al. Plant Physiol, 2008 Mar. PMID 18218969, Free PMC Article
    4. Flux control of sulphate assimilation in Arabidopsis thaliana: adenosine 5'-phosphosulphate reductase is more susceptible than ATP sulphurylase to negative control by thiols. Vauclare P, et al. Plant J, 2002 Sep. PMID 12220264
    5. Regulation of sulfate assimilation by nitrogen in Arabidopsis. Koprivova A, et al. Plant Physiol, 2000 Mar. PMID 10712537, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adenosine 5' phosphosulfate reductase and sulfite oxidase regulate sulfite-induced water loss in Arabidopsis.
      Title: Adenosine 5' phosphosulfate reductase and sulfite oxidase regulate sulfite-induced water loss in Arabidopsis.
    2. structure-based functional studies of APR1C would extend knowledge of the molecular mechanism and regulation of APR
      Title: Crystallization of the C-terminal redox domain of the sulfur-assimilatory enzyme APR1 from Arabidopsis thaliana.
    3. HY5 plays an important role in regulation of APR1 and APR2 gene expression and plant sulfate assimilation
      Title: The key enzyme of sulfate assimilation, adenosine 5'-phosphosulfate reductase, is regulated by HY5 in Arabidopsis.
    4. extensive posttranscriptional regulation
      Title: Complex signaling network in regulation of adenosine 5'-phosphosulfate reductase by salt stress in Arabidopsis roots.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_116699.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenylyl-sulfate reductase (glutathione) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylyl-sulfate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoadenylyl-sulfate reductase (thioredoxin) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within sulfate assimilation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sulfate assimilation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in chloroplast thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    APS reductase 1
    NP_192370.1
    • APS reductase 1 (APR1); FUNCTIONS IN: adenylyl-sulfate reductase activity; INVOLVED IN: response to oxidative stress, sulfate reduction, sulfate assimilation; LOCATED IN: chloroplast, chloroplast stroma, plastid; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Thioredoxin-independent 5'-adenylylsulphate reductase (InterPro:IPR004508), Thioredoxin fold (InterPro:IPR012335), Phosphoadenosine phosphosulphate reductase (InterPro:IPR002500), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: APS reductase 3 (TAIR:AT4G21990.1); Has 5999 Blast hits to 5419 proteins in 1658 species: Archae - 169; Bacteria - 2693; Metazoa - 1288; Fungi - 563; Plants - 600; Viruses - 0; Other Eukaryotes - 686 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      2324878..2327064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116699.3 → NP_192370.1  APS reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192370.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48886, P92979, Q39248, Q56ZY2, Q8LA60
      UniProtKB/TrEMBL
      A0A178UR74, A0A5S9XPW9, A0A654FLW3
      Conserved Domains (1) summary
      TIGR00424
      Location:1 → 465
      APS_reduc; 5'-adenylylsulfate reductase, thioredoxin-independent
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92979.2

    Gene LinkOut

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