RPT2b AAA-type ATPase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: RPT2b
Official Full Name: AAA-type ATPase family protein
Primary source: TAIR:AT2G20140
Locus tag: AT2G20140
See related: Araport:AT2G20140
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: regulatory particle AAA-ATPase 2b; T2G17.6; T2G17_6
Summary: Encodes one of the two RPT2 (26S proteasome subunit RPT2) paralogs: RPT2a (At4g29040) and RPT2b (At2g20140). RPT2b can not complement the rpt2a mutant phenotype. rpt2a rpt2b double mutants are embryo lethal.
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Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

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RPT2 is essential for assembly of the plant 26S proteasome and RPT2a and b isoforms are functionally equivalent. [RPT2b]
Title: The RPT2 subunit of the 26S proteasome directs complex assembly, histone dynamics, and gametophyte and sporophyte development in Arabidopsis.
RPT2a and RPT2b proteins seem to be functionally equivalent in the root apical meristem, but RPT2b is dispensable for meristem function. [RPT2b]
Title: Arabidopsis RPT2a encoding the 26S proteasome subunit is required for various aspects of root meristem maintenance, and regulates gametogenesis redundantly with its homolog, RPT2b.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_127572.4

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within female gamete generation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within maintenance of root meristem identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gamete generation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed

NP_179604.1

AAA-type ATPase family protein; FUNCTIONS IN: hydrolase activity, nucleoside-triphosphatase activity, ATPase activity, nucleotide binding, ATP binding; INVOLVED IN: N-terminal protein myristoylation; LOCATED IN: proteasome complex, plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-type, conserved site (InterPro:IPR003960), 26S proteasome subunit P45 (InterPro:IPR005937); BEST Arabidopsis thaliana protein match is: regulatory particle AAA-ATPase 2A (TAIR:AT4G29040.1); Has 31279 Blast hits to 28945 proteins in 3121 species: Archae - 1433; Bacteria - 10368; Metazoa - 4867; Fungi - 3760; Plants - 3280; Viruses - 37; Other Eukaryotes - 7534 (source: NCBI BLink).

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