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    UXS4 UDP-xylose synthase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819378, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UXS4
    Official Full Name
    UDP-xylose synthase 4
    Primary source
    TAIR:AT2G47650
    Locus tag
    AT2G47650
    See related
    Araport:AT2G47650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T30B22.31; T30B22_31; UDP-xylose synthase 4
    Summary
    encodes a protein similar to UDP-glucuronic acid decarboxylase. UDP-glucuronic acid decarboxylase produces UDP-xylose, which is a substrate for many cell wall carbohydrates including hemicellulose and pectin. UDP-xylose is also known to feedback regulate several cell wall biosynthetic enzymes.
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    Genomic context

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    See UXS4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (19538609..19541585, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene SWITCH/sucrose nonfermenting 3A Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene Small nuclear ribonucleoprotein family protein Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene zinc finger (CCCH type) helicase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of UDP-xylose. Cloning and characterization of a novel Arabidopsis gene family, UXS, encoding soluble and putative membrane-bound UDP-glucuronic acid decarboxylase isoforms. Harper AD, et al. Plant Physiol, 2002 Dec. PMID 12481102, Free PMC Article
    2. Role of UDP-Glucuronic Acid Decarboxylase in Xylan Biosynthesis in Arabidopsis. Kuang B, et al. Mol Plant, 2016 Aug 1. PMID 27179920
    3. Large-scale characterization of integral proteins from Arabidopsis vacuolar membrane by two-dimensional liquid chromatography. Szponarski W, et al. Proteomics, 2004 Feb. PMID 14760709
    4. Label-free protein quantification for plant Golgi protein localization and abundance. Nikolovski N, et al. Plant Physiol, 2014 Oct. PMID 25122472, Free PMC Article
    5. Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization. Parsons HT, et al. Plant Cell, 2019 Sep. PMID 31266899, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    NM_001202843.1
    NM_130333.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucuronate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucuronate decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-xylose metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in UDP-D-xylose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi trans cisterna HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in endosome HDA PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in trans-Golgi network HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    UDP-xylose synthase 4
    NP_001189772.1
    • UDP-xylose synthase 4 (UXS4); CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G62830.2).
    NP_182287.1
    • UDP-xylose synthase 4 (UXS4); FUNCTIONS IN: UDP-glucuronate decarboxylase activity, catalytic activity; INVOLVED IN: nucleotide-sugar metabolic process, D-xylose metabolic process; LOCATED IN: Golgi apparatus, plasma membrane, vacuole, membrane; EXPRESSED IN: cotyledon, male gametophyte, cultured cell, pollen tube, leaf; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G62830.2); Has 44652 Blast hits to 44610 proteins in 2978 species: Archae - 851; Bacteria - 26010; Metazoa - 746; Fungi - 333; Plants - 1297; Viruses - 49; Other Eukaryotes - 15366 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19538609..19541585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130333.4 → NP_182287.1  UDP-xylose synthase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182287.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S8T4
      UniProtKB/TrEMBL
      A0A178VT54, A0A654F802
      Conserved Domains (2) summary
      PLN02206
      Location:1 → 434
      PLN02206; UDP-glucuronate decarboxylase
      cd05230
      Location:122 → 424
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs

    2. NM_001202843.1 → NP_001189772.1  UDP-xylose synthase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F802, C0Z2I3
      Conserved Domains (1) summary
      PLN02206
      Location:1 → 440
      PLN02206; UDP-glucuronate decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S8T4.1

    Gene LinkOut

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