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    Vps33B Vacuolar protein sorting 33B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps33Bprovided by FlyBase
    Official Full Name
    Vacuolar protein sorting 33Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039335
    Locus tag
    Dmel_CG5127
    See related
    AllianceGenome:FB:FBgn0039335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5127; Dmel\CG5127; dVps33B; Vps 33B; Vps33b; VPS33b; VPS33B
    Summary
    Enables syntaxin binding activity. Involved in cellular response to peptidoglycan; defense response to bacterium; and immune response. Part of HOPS complex. Is expressed in adult head. Used to study ARC syndrome. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; arthrogryposis, renal dysfunction, and cholestasis 1; cholestasis; kidney disease; and progressive familial intrahepatic cholestasis. Orthologous to human VPS33B (VPS33B late endosome and lysosome associated). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vps33B in Genome Data Viewer
    Location:
    96E1-96E1; 3-88 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25473490..25475756)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21299212..21301478)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Furin 1 Neighboring gene uncharacterized protein Neighboring gene Mucin 96D Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 28 Neighboring gene XNP

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The chromatin remodelling factor dATRX is involved in heterochromatin formation. Bassett AR, et al. PLoS One, 2008 May 7. PMID 18461125, Free PMC Article
    2. ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination. Akbar MA, et al. Immunity, 2016 Aug 16. PMID 27496733, Free PMC Article
    3. Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. Gissen P, et al. Hum Mol Genet, 2005 May 15. PMID 15790593
    4. Tethering complexes in the endocytic pathway: CORVET and HOPS. Solinger JA, et al. FEBS J, 2013 Jun. PMID 23351085
    5. Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules. Pulipparacharuvil S, et al. J Cell Sci, 2005 Aug 15. PMID 16046475

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that Vps33B function is critical for determining the fate of signaling endosomes formed following pattern-recognition receptors activation
      Title: ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to peptidoglycan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to peptidoglycan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of SNARE complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CORVET complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CORVET complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of HOPS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HOPS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting 33B
    Names
    CG5127-PA
    Vps33B-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25473490..25475756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143138.3 → NP_651395.1  vacuolar protein sorting 33B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZS6, Q9VBR1
      Related
      FBpp0084210
      Conserved Domains (1) summary
      pfam00995
      Location:31 → 406
      Sec1; Sec1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZS6 Q8SZS6
    Q9VBR1 Q9VBR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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