S6KL S6 Kinase Like [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: S6KLprovided by FlyBase
Official Full Name: S6 Kinase Likeprovided by FlyBase
Primary source: FLYBASE:FBgn0283473
Locus tag: Dmel_CG7001
See related: AllianceGenome:FB:FBgn0283473
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3-10; BcdK; bin4; Bin4; BIN4; CG7001; Dmel\CG7001; pk17e; Pk17E; PK17E; Pk?4
Summary: Enables protein serine/threonine kinase activity. Involved in negative regulation of BMP signaling pathway and negative regulation of neuromuscular junction development. Located in cytosol. Is expressed in organism. Orthologous to human RSKR (ribosomal protein S6 kinase related). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 17D6-17E1; 1-60 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18788464..18806057)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18682497..18700090)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results together demonstrate for the first time that S6KL regulates synaptic development and function by facilitating proteasomal degradation of the BMP receptor Tkv.
Title: Drosophila S6 Kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor thickveins.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: S6 kinase like

Names: Bcd interacting protein K; CG7001-PA; CG7001-PB; CG7001-PC; S6KL-PA; S6KL-PB; S6KL-PC; bicoid interacting protein 4; protein kinase-like 17E

NP_001245742.1

EC 2.7.11.1

NP_001245743.1

EC 2.7.11.1

NP_524861.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

18788464..18806057

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080122.4 → NP_524861.2 S6 kinase like, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524861.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B9EQU9, M9NEP2, M9NFD4, O96630, Q9VWQ2

Related

FBpp0074405

Conserved Domains (2) summary

smart00220
Location:159 → 431

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05123
Location:167 → 354

STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases
NM_001258814.2 → NP_001245743.1 S6 kinase like, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245743.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VWQ2

Conserved Domains (2) summary

smart00220
Location:157 → 429

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05123
Location:165 → 352

STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases
NM_001258813.1 → NP_001245742.1 S6 kinase like, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245742.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VWQ2

Conserved Domains (1) summary

cl21453
Location:1 → 109

PKc_like; Protein Kinases, catalytic domain