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    Mob4 MOB kinase activator 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35576, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mob4provided by FlyBase
    Official Full Name
    MOB kinase activator 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0259483
    Locus tag
    Dmel_CG3403
    See related
    AllianceGenome:FB:FBgn0259483
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3403; Dmel\CG3403; dmob4; dMob4; Dmob4; DMob4; MOB4
    Summary
    Involved in several processes, including axo-dendritic transport; regulation of nervous system development; and regulation of signal transduction. Located in cytosol and terminal bouton. Part of FAR/SIN/STRIPAK complex. Is expressed in several structures, including adult head; adult heart; central brain primordium; embryonic/larval midgut primordium; and ganglia. Orthologous to human MOB4 (MOB family member 4, phocein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mob4 in Genome Data Viewer
    Location:
    42C5-42C5; 2-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6695114..6696661, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2582619..2584166, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribonuclease P/MRP subunit p25 Neighboring gene antisense RNA:CR44165 Neighboring gene uncharacterized protein Neighboring gene Tyrosine decarboxylase 2 Neighboring gene uncharacterized protein Neighboring gene Rab2 Neighboring gene uncharacterized protein Neighboring gene chaski Neighboring gene mir-4975 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mob4 is essential for spermatogenesis in Drosophila melanogaster. Santos IB, et al. Genetics, 2023 Aug 9. PMID 37259670, Free PMC Article
    2. Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility. Cole SH, et al. J Biol Chem, 2005 Apr 15. PMID 15691831
    3. Mob4 plays a role in spindle focusing in Drosophila S2 cells. Trammell MA, et al. J Cell Sci, 2008 Apr 15. PMID 18388316, Free PMC Article
    4. STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation. Gil-Ranedo J, et al. Cell Rep, 2019 Jun 4. PMID 31167138, Free PMC Article
    5. lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK. Parsons LM, et al. Cancers (Basel), 2014 Apr 16. PMID 24743776, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mob4 is essential for spermatogenesis in Drosophila melanogaster.
      Title: Mob4 is essential for spermatogenesis in Drosophila melanogaster.
    2. Mob4/Cka/Mts functions as an intrinsic molecular switch coordinating Hippo and InR/PI3K/Akt pathways and enabling neural stem cells reactivation.
      Title: STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation.
    3. findings suggest a novel role for Phocein proteins in the regulation of axonal transport, neurite elongation, synapse formation, and microtubule organization
      Title: DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axo-dendritic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to nutrient IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction HGI PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MOB kinase activator 4
    Names
    CG3403-PA
    CG3403-PB
    Mob4-PA
    Mob4-PB
    Mps one binder kinase activator-like 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6695114..6696661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136385.4 → NP_610229.1  MOB kinase activator 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610229.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K0E3
      Related
      FBpp0085474
      Conserved Domains (2) summary
      pfam03637
      Location:53 → 208
      Mob1_phocein; Mob1/phocein family
      cl17171
      Location:14 → 29
      PH-like; Pleckstrin homology-like domain

    2. NM_001259222.2 → NP_001246151.1  MOB kinase activator 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246151.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6X9
      Conserved Domains (1) summary
      pfam03637
      Location:53 → 211
      Mob1_phocein; Mob1/phocein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6X9 A0A0B4K6X9
    Q7K0E3.1 Q7K0E3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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