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    Hs2st Heparan sulfate 2-O-sulfotransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44433, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Hs2stprovided by FlyBase
    Official Full Name
    Heparan sulfate 2-O-sulfotransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024230
    Locus tag
    Dmel_CG10234
    See related
    AllianceGenome:FB:FBgn0024230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10234; dHS2ST; Dmel\CG10234; dmHS-2OST; dmHs2st; DmHs2st; HS2ST; Hs2st-2
    Summary
    Enables heparan sulfate 2-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and open tracheal system development. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in lamina furrow and organism. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hs2st in Genome Data Viewer
    Location:
    37E1-37E1; 2-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19442833..19444750, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19442833..19444750, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rab9 Neighboring gene uncharacterized protein Neighboring gene Ran GTPase activating protein Neighboring gene Topoisomerase 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of Drosophila heparan sulfate 6-O-endosulfatase in sulfation compensation. Dejima K, et al. J Biol Chem, 2013 Mar 1. PMID 23339195, Free PMC Article
    2. Large-scale selective sweep among Segregation Distorter chromosomes in African populations of Drosophila melanogaster. Presgraves DC, et al. PLoS Genet, 2009 May. PMID 19412335, Free PMC Article
    3. Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. Xu D, et al. J Biol Chem, 2007 Mar 16. PMID 17227754
    4. Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila. Merrill C, et al. Science, 1999 Mar 12. PMID 10073941
    5. In vivo manipulation of heparan sulfate structure and its effect on Drosophila development. Kamimura K, et al. Glycobiology, 2011 May. PMID 21147759, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heparan sulfate 2-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparan sulfate 2-O-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in open tracheal system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heparan sulfate 2-O-sulfotransferase
    Names
    2-O sulfotransferase
    CG10234-PA
    HS 2-O
    HS 2-O-sulfotransferase
    Hs2st-PA
    heparan-sulfate-2-sulfotransferase
    NP_477339.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19442833..19444750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057991.5 → NP_477339.1  heparan sulfate 2-O-sulfotransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25722, Q9VIW4
      Related
      FBpp0080826
      Conserved Domains (1) summary
      pfam03567
      Location:70 → 325
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25722.2 P25722

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