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    CG13430 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772580, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG13430provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034518
    Locus tag
    Dmel_CG13430
    See related
    AllianceGenome:FB:FBgn0034518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33008; Dmel\CG13430; SP70
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36); PRSS53 (serine protease 53); and TMPRSS4 (transmembrane serine protease 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13430 in Genome Data Viewer
    Location:
    57A5-57A5; 2-91 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20550334..20552090, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16437839..16439595, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 57e Neighboring gene Cuticular protein 57A Neighboring gene Odorant-binding protein 57d Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene lateral muscles scarcer Neighboring gene Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Neighboring gene antisense RNA:CR44653 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Odorant-binding proteins OBP57d and OBP57e affect taste perception and host-plant preference in Drosophila sechellia. Matsuo T, et al. PLoS Biol, 2007 May. PMID 17456006, Free PMC Article
    2. RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance. Pawar V, et al. J Biomol Screen, 2011 Apr. PMID 21364088, Free PMC Article
    3. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
    4. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400
    5. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13430-PA
    CG13430-PB
    NP_001027441.1
    NP_001027442.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20550334..20552090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032271.2 → NP_001027442.1  uncharacterized protein Dmel_CG13430, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027442.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1E3
      Conserved Domains (2) summary
      smart00020
      Location:31 → 259
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:32 → 262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001032270.2 → NP_001027441.1  uncharacterized protein Dmel_CG13430, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1E3
      Conserved Domains (2) summary
      smart00020
      Location:31 → 259
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:32 → 262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K1E3 Q7K1E3

    Gene LinkOut

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