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    Nagk N-acetylglucosamine kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nagkprovided by FlyBase
    Official Full Name
    N-acetylglucosamine kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038321
    Locus tag
    Dmel_CG6218
    See related
    AllianceGenome:FB:FBgn0038321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6218; Dmel\CG6218; DNagk
    Summary
    Predicted to enable N-acetylglucosamine kinase activity. Predicted to be involved in N-acetylglucosamine catabolic process; UDP-N-acetylglucosamine biosynthetic process; and carbohydrate phosphorylation. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval lateral glial cell; ganglia; and primary tracheal branch. Orthologous to human NAGK (N-acetylglucosamine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nagk in Genome Data Viewer
    Location:
    88F1-88F1; 3-57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15337908..15343256, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11163630..11168978, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene easter Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene FK506-binding protein 39kD Neighboring gene Cytoplasmic FMR1 interacting protein Neighboring gene Seryl-tRNA synthetase, mitochondrial Neighboring gene Surfeit 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway. Neitzel LR, et al. Mech Dev, 2019 Apr. PMID 30904594, Free PMC Article
    2. An endogenous small interfering RNA pathway in Drosophila. Czech B, et al. Nature, 2008 Jun 5. PMID 18463631, Free PMC Article
    3. Subtypes of glial cells in the Drosophila embryonic ventral nerve cord as related to lineage and gene expression. Beckervordersandforth RM, et al. Mech Dev, 2008 May-Jun. PMID 18296030
    4. The early life of a fly glial cell. Altenhein B, et al. Wiley Interdiscip Rev Dev Biol, 2016 Jan-Feb. PMID 26224590
    5. Translational profiling of clock cells reveals circadianly synchronized protein synthesis. Huang Y, et al. PLoS Biol, 2013 Nov. PMID 24348200, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetylglucosamine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylglucosamine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in carbohydrate phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylglucosamine kinase
    Names
    CG6218-PA
    CG6218-PB
    Nagk-PA
    Nagk-PB
    NP_001262598.1
    NP_650448.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15337908..15343256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142191.1 → NP_650448.1  N-acetylglucosamine kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650448.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF86
      Related
      FBpp0082573, FBtr0083119
      Conserved Domains (1) summary
      cl17037
      Location:1 → 285
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_001275669.1 → NP_001262598.1  N-acetylglucosamine kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262598.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF86
      Conserved Domains (1) summary
      cl17037
      Location:1 → 285
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VF86 Q9VF86

    Gene LinkOut

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