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    TwdlS TweedleS [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TwdlSprovided by FlyBase
    Official Full Name
    TweedleSprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039443
    Locus tag
    Dmel_CG14242
    See related
    AllianceGenome:FB:FBgn0039443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14242; Dmel\CG14242; twdlS
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TwdlS in Genome Data Viewer
    Location:
    97C2-97C2; 3-91 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26636688..26637557)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22462410..22463279)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TweedleH Neighboring gene TweedleR Neighboring gene long non-coding RNA:CR46233 Neighboring gene TweedleD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic dissection of intraspecific variation in a male-specific sexual trait in Drosophila melanogaster. Cloud-Richardson KM, et al. Heredity (Edinb), 2016 Dec. PMID 27530909, Free PMC Article
    2. Tweedle proteins form extracellular two-dimensional structures defining body and cell shape in Drosophila melanogaster. Zuber R, et al. Open Biol, 2020 Dec. PMID 33292106, Free PMC Article
    3. Sex- and segment-specific modulation of gene expression profiles in Drosophila. Barmina O, et al. Dev Biol, 2005 Dec 15. PMID 16269142
    4. Transcriptional changes revealed genes and pathways involved in the deficient testis caused by the inhibition of alkaline ceramidase (Dacer) in Drosophila melanogaster. Zhang MJ, et al. Arch Insect Biochem Physiol, 2021 Mar. PMID 33590535
    5. Transcriptomic Insights into the Insect Immune Response to Nematode Infection. Eleftherianos I, et al. Genes (Basel), 2021 Jan 30. PMID 33573306, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in body morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chitin-based cuticle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    TweedleS
    Names
    CG14242-PA
    TwdlS-PA
    tweedle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26636688..26637557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143234.2 → NP_651491.1  TweedleS [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651491.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I1W6K9, Q9VBD3
      Related
      FBpp0084406
      Conserved Domains (1) summary
      smart00690
      Location:45 → 145
      DM5; Domain of unknown function, currently peculiar to Drosophila
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBD3 Q9VBD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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