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    WOL CHASE domain containing histidine kinase protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814714, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WOL
    Official Full Name
    CHASE domain containing histidine kinase protein
    Primary source
    TAIR:AT2G01830
    Locus tag
    AT2G01830
    See related
    Araport:AT2G01830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AHK4; ARABIDOPSIS HISTIDINE KINASE 4; ATCRE1; CRE1; CYTOKININ RESPONSE 1; T23K3.2; T23K3_2; WOL1; WOODEN LEG; WOODEN LEG 1
    Summary
    Histidine kinase: cytokinin-binding receptor that transduces cytokinin signals across the plasma membrane
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    Genomic context

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    See WOL in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Sequence:
    Chromosome: 2; NC_003071.7 (362983..369707, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene PLATZ transcription factor family protein Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene pseudo Neighboring gene endoxyloglucan transferase A3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis sensor His-kinase, AHk4, can respond to cytokinins. Suzuki T, et al. Plant Cell Physiol, 2001 Feb. PMID 11230563
    2. Perception and signal transduction of cytokinins. Kakimoto T. Annu Rev Plant Biol, 2003. PMID 14503005
    3. A novel regulatory pathway of sulfate uptake in Arabidopsis roots: implication of CRE1/WOL/AHK4-mediated cytokinin-dependent regulation. Maruyama-Nakashita A, et al. Plant J, 2004 Jun. PMID 15144379
    4. A live cell hormone-binding assay on transgenic bacteria expressing a eukaryotic receptor protein. Romanov GA, et al. Anal Biochem, 2005 Dec 1. PMID 16246292
    5. Cytokinin receptors are required for normal development of auxin-transporting vascular tissues in the hypocotyl but not in adventitious roots. Kuroha T, et al. Plant Cell Physiol, 2006 Feb. PMID 16357038

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum.
      Title: Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum.
    2. Cytokinins promote actin bundling and the resultant second rapid cell elongation through activating the signaling pathway involving the cytokinin receptors ARABIDOPSIS HISTIDINE KINASE3 (AHK3) and AHK4 and the B-type transcription factor ARABIDOPSIS RESPONSE REGULATOR2.
      Title: Actin Reorganization Triggers Rapid Cell Elongation in Roots.
    3. an important role for endogenous cytokinin biosynthesis and AHK4-mediated cytokinin signalling in the control of de novo-induced organ identity.
      Title: Cytokinin signalling regulates organ identity via the AHK4 receptor in Arabidopsis.
    4. Results show the stress physiology function of histidine kinaseS AHK2, AHK3 AND AHK4.
      Title: Stress physiology functions of the Arabidopsis histidine kinase cytokinin receptors.
    5. N6-(benzyloxymethyl)adenosine is a novel anticytokinin, an antagonist of cytokinin receptor CRE1/AHK4 of Arabidopsis.
      Title: N⁶-(benzyloxymethyl)adenosine is a novel anticytokinin, an antagonist of cytokinin receptor CRE1/AHK4 of Arabidopsis.
    6. Programmed cell death induced by cytokinin is mediated by the cytokinin receptor CRE1.
      Title: Programmed cell death induced by high levels of cytokinin in Arabidopsis cultured cells is mediated by the cytokinin receptor CRE1/AHK4.
    7. AHK2 and AHK3 signal specifically in leaf parenchyma cells, AHK3 in stomata cells, and CRE1/AHK4 in the root vasculature. CRE1/AHK4 can functionally replace AHK2 but not AHK3.
      Title: The specificity of cytokinin signalling in Arabidopsis thaliana is mediated by differing ligand affinities and expression profiles of the receptors.
    8. The sugar effect in shoots of phosphate-starved plants was particularly enhanced in the cre1 ahk3 double mutant.
      Title: Interaction between phosphate-starvation, sugar, and cytokinin signaling in Arabidopsis and the roles of cytokinin receptors CRE1/AHK4 and AHK3.
    9. growth and development of the ahk2 ahk3 ahk4 triple mutant were markedly inhibited in various tissues and organs, including the roots and leaves in the vegetative growth phase and the influorescence meristem in the reproductive phase
      Title: Histidine kinase homologs that act as cytokinin receptors possess overlapping functions in the regulation of shoot and root growth in Arabidopsis.
    10. the diverse cytokinin compounds might have specific functions in the numerous cytokinin-regulated processes, which may depend in turn on different receptors and their associated signalling pathways
      Title: Two cytokinin receptors of Arabidopsis thaliana, CRE1/AHK4 and AHK3, differ in their ligand specificity in a bacterial assay.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001335080.1
    NM_001335081.1
    NM_001335082.1
    NM_126244.3
    NM_179594.2
    NM_201667.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cytokinin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytokinin receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables osmosensor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein histidine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein histidine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane histidine kinase cytokinin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to phosphate starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to sucrose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic root morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within osmosensory signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of meristem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of shoot system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sulfate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    CHASE domain containing histidine kinase protein
    NP_565277.1
    • WOODEN LEG (WOL); FUNCTIONS IN: osmosensor activity, cytokine binding, cytokinin receptor activity, protein histidine kinase activity, phosphoprotein phosphatase activity; INVOLVED IN: in 7 processes; LOCATED IN: membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), CHASE (InterPro:IPR006189), Signal transduction histidine kinase, core (InterPro:IPR005467), ATPase-like, ATP-binding domain (InterPro:IPR003594), CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); BEST Arabidopsis thaliana protein match is: histidine kinase 2 (TAIR:AT5G35750.1); Has 136787 Blast hits to 109703 proteins in 3011 species: Archae - 761; Bacteria - 121785; Metazoa - 32; Fungi - 2267; Plants - 2388; Viruses - 27; Other Eukaryotes - 9527 (source: NCBI BLink).
    NP_849925.1
    • WOODEN LEG (WOL); FUNCTIONS IN: osmosensor activity, cytokine binding, cytokinin receptor activity, protein histidine kinase activity, phosphoprotein phosphatase activity; INVOLVED IN: in 7 processes; LOCATED IN: membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), CHASE (InterPro:IPR006189), Signal transduction histidine kinase, core (InterPro:IPR005467), ATPase-like, ATP-binding domain (InterPro:IPR003594), CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); BEST Arabidopsis thaliana protein match is: histidine kinase 2 (TAIR:AT5G35750.1); Has 134660 Blast hits to 108037 proteins in 2975 species: Archae - 759; Bacteria - 119664; Metazoa - 32; Fungi - 2267; Plants - 2388; Viruses - 27; Other Eukaryotes - 9523 (source: NCBI BLink).
    NP_973396.1
    • WOODEN LEG (WOL); FUNCTIONS IN: osmosensor activity, cytokine binding, cytokinin receptor activity, protein histidine kinase activity, phosphoprotein phosphatase activity; INVOLVED IN: in 7 processes; LOCATED IN: membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), CHASE (InterPro:IPR006189), Signal transduction histidine kinase, core (InterPro:IPR005467), ATPase-like, ATP-binding domain (InterPro:IPR003594), CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); BEST Arabidopsis thaliana protein match is: histidine kinase 2 (TAIR:AT5G35750.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      362983..369707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_201667.1 → NP_973396.1  CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973396.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W0T1, A0A5S9WWG0, A0A654ER67
      Conserved Domains (2) summary
      PRK11107
      Location:435 → 1052
      PRK11107; hybrid sensory histidine kinase BarA; Provisional
      pfam03924
      Location:177 → 359
      CHASE; CHASE domain

    2. NM_001335081.1 → NP_001324427.1  CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B026, A0A5S9WWG0, A0A654ER67

    3. NM_179594.2 → NP_849925.1  CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849925.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5YY60, A5YY75, Q9C5T8, Q9C5T9, Q9C5U0, Q9FDZ3, Q9SIT0
      UniProtKB/TrEMBL
      A0A654ER67
      Conserved Domains (2) summary
      PRK11107
      Location:458 → 1075
      PRK11107; hybrid sensory histidine kinase BarA; Provisional
      pfam03924
      Location:200 → 382
      CHASE; CHASE domain

    4. NM_001335080.1 → NP_001324428.1  CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W0T1, A0A5S9WWG0, A0A654ER67
      Conserved Domains (2) summary
      PRK11107
      Location:435 → 1052
      PRK11107; hybrid sensory histidine kinase BarA; Provisional
      pfam03924
      Location:177 → 359
      CHASE; CHASE domain

    5. NM_001335082.1 → NP_001324429.1  CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W0T1, A0A5S9WWG0, A0A654ER67
      Conserved Domains (2) summary
      PRK11107
      Location:435 → 1052
      PRK11107; hybrid sensory histidine kinase BarA; Provisional
      pfam03924
      Location:177 → 359
      CHASE; CHASE domain

    6. NM_126244.3 → NP_565277.1  CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565277.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W0T1, A0A5S9WWG0, A0A654ER67
      Conserved Domains (2) summary
      PRK11107
      Location:435 → 1052
      PRK11107; hybrid sensory histidine kinase BarA; Provisional
      pfam03924
      Location:177 → 359
      CHASE; CHASE domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5U0.1

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