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    CG8419 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8419provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031999
    Locus tag
    Dmel_CG8419
    See related
    AllianceGenome:FB:FBgn0031999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8419
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Is expressed in spermatozoon. Orthologous to human TRIM45 (tripartite motif containing 45). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8419 in Genome Data Viewer
    Location:
    28F1-28F2; 2-30 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8206171..8209637)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8206171..8209637)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44120 Neighboring gene long non-coding RNA:CR44121 Neighboring gene Suppressor of variegation 205 Neighboring gene Single stranded-binding protein c31A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Origin and diversification of TRIM ubiquitin ligases. Marín I. PLoS One, 2012. PMID 23185523, Free PMC Article
    2. Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties. Sardiello M, et al. BMC Evol Biol, 2008 Aug 1. PMID 18673550, Free PMC Article
    3. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Candia N, et al. Hum Genet, 2023 Aug. PMID 37368047
    4. Identification and characterization of genes involved in embryonic crystal cell formation during Drosophila hematopoiesis. Milchanowski AB, et al. Genetics, 2004 Sep. PMID 15454546, Free PMC Article
    5. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8419-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8206171..8209637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135349.3 → NP_609193.1  uncharacterized protein Dmel_CG8419 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609193.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3ZAM2, Q9VLR7
      Related
      FBpp0079210
      Conserved Domains (5) summary
      smart00184
      Location:308 → 334
      RING; Ring finger
      smart00557
      Location:751 → 849
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:748 → 846
      Filamin; Filamin/ABP280 repeat
      pfam00643
      Location:537 → 576
      zf-B_box; B-box zinc finger
      cl23765
      Location:583 → 703
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLR7 Q9VLR7

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