y yellow [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: yprovided by FlyBase
Official Full Name: yellowprovided by FlyBase
Primary source: FLYBASE:FBgn0004034
Locus tag: Dmel_CG3757
See related: AllianceGenome:FB:FBgn0004034
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3757; Dmel\CG3757; EG:125H10.2; T6; Y
Summary: Involved in several processes, including cuticle pigmentation; male courtship behavior, veined wing extension; and melanin biosynthetic process. Located in cell hair; cytoplasm; and extracellular region. Is expressed in several structures, including cephalopharyngeal skeleton; eo-type sensillum; epidermis; gut section; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 1A5-1A5; 1-0 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (356509..361245)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (250542..255278)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sex combs require yellow expression for normal male mating success.
Title: The yellow gene influences Drosophila male mating success through sex comb melanization.
The architecture of yellow cis-regulatory sequences (from D. melanogaster, D. pseudoobscura, and D. willistoni) is less modular and more variable among species than previously described, with the observed organization of enhancer activities potentially making yellow expression more robust, as well as more amenable to evolutionary change.
Title: Redundant and Cryptic Enhancer Activities of the Drosophilayellow Gene.
First, the authors show that y is required for the production of black Dopamine-melanin. Then, using in situ hybridization, they show that the expression of y is strongly modulated by temperature in the abdominal epidermis of pharate females but not in bristles.
Title: Modulation of yellow expression contributes to thermal plasticity of female abdominal pigmentation in Drosophila melanogaster.
the negative effect of transcription of the Drosophila genes white and yellow remained, but weakened with increased distance between the leading promoter and enhancer and with decreased distance between the enhancer and target promoter
Title: [The Effect of Transcription on Enhancer Activity in Drosophila melanogaster].
role of yellow gene sequences from -70 to-146 bp in the transcriptional activation at the end of terminally truncated chromosome in Drosophila melanogaster
Title: Role of yellow gene sequences from -70 to-146 bp in the transcriptional activation at the end of terminally truncated chromosome in Drosophila melanogaster.
Study shows that the polyadenylation signal from the yellow gene cannot efficiently terminate transcription when located in the gene intron and that the Su(Hw)-dependent 1A2 insulator cannot enhance the polyadenylation signal efficiency
Title: Study of functional activity of the 1A2 insulator and polyadenylation signal in intron of the yellow gene of Drosophila melanogaster.
Data show that flies lacking yar RNAs are viable and show no overt morphological defects, consistent with maintained transcriptional regulation of the adjacent yellow (y) and achaete (ac) genes.
Title: A conserved long noncoding RNA affects sleep behavior in Drosophila.
Both insulators support basal activity of the yellow and white promoters in eyes.
Title: Insulators form gene loops by interacting with promoters in Drosophila.
Data indicate that homolog pairing at yellow is efficient, as complementation was disrupted only in the presence of chromosomal rearrangements that break <or=650 kbp from yellow.
Title: Effects of chromosomal rearrangements on transvection at the yellow gene of Drosophila melanogaster.
Yellow locus residing at the very end of X chromosome (region 1A5-8 of cytologic map) carries significantly more transposon than retrotransposon-induced mutations, as compared to white locus (regions 3C2).
Title: [Polymorphism of yellow locus in Drosophila melanogaster from natural populations].

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables dopachrome isomerase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cuticle pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cuticle pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental pigmentation	IEP Inferred from Expression Pattern more info	PubMed
involved_in developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in male courtship behavior, veined wing extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanin biosynthetic process from tyrosine	TAS Traceable Author Statement more info	PubMed
involved_in regulation of adult chitin-containing cuticle pigmentation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell hair	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed