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    alphaTry alphaTrypsin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48316, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alphaTryprovided by FlyBase
    Official Full Name
    alphaTrypsinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003863
    Locus tag
    Dmel_CG18444
    See related
    AllianceGenome:FB:FBgn0003863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha; alpha-Try; AlphaTry; CG18444; DmAlphaTry; Dmel\CG18444; SP102; Try
    Summary
    Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head and larval digestive system. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
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    Try the new Transcript table

    Genomic context

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    See alphaTry in Genome Data Viewer
    Location:
    47F4-47F4; 2-64 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11344260..11345119, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7231765..7232624, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene etaTrypsin Neighboring gene thetaTrypsin Neighboring gene epsilonTrypsin Neighboring gene betaTrypsin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gene family in Drosophila melanogaster coding for trypsin-like enzymes. Davis CA, et al. Nucleic Acids Res, 1985 Sep 25. PMID 2414727, Free PMC Article
    2. Direct protein-protein interaction network for insecticide resistance based on subcellular localization analysis in Drosophila melanogaster. Zhang G, et al. J Environ Sci Health B, 2020. PMID 32567974
    3. A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes. Bozler J, et al. PLoS Genet, 2017 Oct. PMID 29084214, Free PMC Article
    4. Concerted evolution within a trypsin gene cluster in Drosophila. Wang S, et al. Mol Biol Evol, 1999 Sep. PMID 10486967
    5. Alkaline Ceramidase Mediates the Oxidative Stress Response in Drosophila melanogaster Through Sphingosine. Zhang CH, et al. J Insect Sci, 2019 May 1. PMID 31115476, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alphaTrypsin
    Names
    CG18444-PA
    alphaTry-PA
    NP_476771.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11344260..11345119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057423.4 → NP_476771.1  alphaTrypsin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476771.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P04814, Q541G0, Q9V5Y2
      Related
      FBpp0087257
      Conserved Domains (1) summary
      smart00020
      Location:30 → 249
      Tryp_SPc; Trypsin-like serine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04814.1 P04814

    Gene LinkOut

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