ppl pumpless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pplprovided by FlyBase
Official Full Name: pumplessprovided by FlyBase
Primary source: FLYBASE:FBgn0027945
Locus tag: Dmel_CG7758
See related: AllianceGenome:FB:FBgn0027945
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7758; Dmel\CG7758; l(3)00217; l(3)78Cb
Summary: Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to be part of glycine cleavage complex. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and fat body. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome. Orthologous to human GCSH (glycine cleavage system protein H). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21280491..21281506, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21273591..21274606, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in glycine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycine decarboxylation via glycine cleavage system	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine decarboxylation via glycine cleavage system	IEA Inferred from Electronic Annotation more info
involved_in glycine decarboxylation via glycine cleavage system	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of glycine cleavage complex	IBA Inferred from Biological aspect of Ancestor more info
part_of glycine cleavage complex	IEA Inferred from Electronic Annotation more info
part_of glycine cleavage complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info