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    PRR11 proline rich 11 [ Homo sapiens (human) ]

    Gene ID: 55771, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PRR11provided by HGNC
    Official Full Name
    proline rich 11provided by HGNC
    Primary source
    HGNC:HGNC:25619
    See related
    Ensembl:ENSG00000068489 MIM:615920; AllianceGenome:HGNC:25619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Involved in regulation of cell cycle. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bone marrow (RPKM 3.3), lymph node (RPKM 2.7) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRR11 in Genome Data Viewer
    Location:
    17q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (59155746..59206709)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (60023844..60074810)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (57233107..57284070)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8777 Neighboring gene microRNA 454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12502 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:57235593-57236792 Neighboring gene microRNA 301a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12503 Neighboring gene speedy/RINGO cell cycle regulator family member E22, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:57259739-57260240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:57297898-57298448 Neighboring gene SMG8 nonsense mediated mRNA decay factor Neighboring gene glycerophosphodiester phosphodiesterase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Proline-rich protein 11 silencing inhibits hepatocellular carcinoma growth and epithelial-mesenchymal transition through β-catenin signaling. Qiao W, et al. Gene, 2019 Jan 10. PMID 30248355
    2. PRR11 regulates late-S to G2/M phase progression and induces premature chromatin condensation (PCC). Zhang C, et al. Biochem Biophys Res Commun, 2015 Mar 13. PMID 25666944
    3. The prognostic potential and oncogenic effects of PRR11 expression in hilar cholangiocarcinoma. Chen Y, et al. Oncotarget, 2015 Aug 21. PMID 25971332, Free PMC Article
    4. RNAi-mediated silencing of praline-rich gene causes growth reduction in human lung cancer cells. Zhao Q. Int J Clin Exp Pathol, 2015. PMID 25973065, Free PMC Article
    5. PRR11 promotes ccRCC tumorigenesis by regulating E2F1 stability. Chen S, et al. JCI Insight, 2021 Oct 8. PMID 34499617, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prognostic value of PRR11 and immune cell infiltration in Ewing sarcoma.
      Title: Prognostic value of PRR11 and immune cell infiltration in Ewing sarcoma.
    2. ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.
      Title: ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.
    3. Predictive significance of PRR11 in prognosis and immune infiltration of glioma patients.
      Title: Predictive significance of PRR11 in prognosis and immune infiltration of glioma patients.
    4. Proline-rich 11 (PRR11) promotes the progression of cutaneous squamous cell carcinoma by activating the EGFR signaling pathway.
      Title: Proline-rich 11 (PRR11) promotes the progression of cutaneous squamous cell carcinoma by activating the EGFR signaling pathway.
    5. PRR11 is a prognostic biomarker and correlates with immune infiltrates in bladder urothelial carcinoma.
      Title: PRR11 is a prognostic biomarker and correlates with immune infiltrates in bladder urothelial carcinoma.
    6. Clinical significance and effect of PRR 11 up-regulation on the malignancy of osteosarcoma.
      Title: Clinical significance and effect of PRR 11 up-regulation on the malignancy of osteosarcoma.
    7. PRR11 Promotes Proliferation and Migration of Colorectal Cancer through Activating the EGFR/ERK/AKT Pathway via Increasing CTHRC1.
      Title: PRR11 Promotes Proliferation and Migration of Colorectal Cancer through Activating the EGFR/ERK/AKT Pathway via Increasing CTHRC1.
    8. PRR11 unveiled as a top candidate biomarker within the RBM3-regulated transcriptome in pancreatic cancer.
      Title: PRR11 unveiled as a top candidate biomarker within the RBM3-regulated transcriptome in pancreatic cancer.
    9. PRR11 promotes ccRCC tumorigenesis by regulating E2F1 stability.
      Title: PRR11 promotes ccRCC tumorigenesis by regulating E2F1 stability.
    10. MicroRNA-26b-5p suppresses the proliferation of tongue squamous cell carcinoma via targeting proline rich 11 (PRR11).
      Title: MicroRNA-26b-5p suppresses the proliferation of tongue squamous cell carcinoma via targeting proline rich 11 (PRR11).
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11029

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proline-rich protein 11
    Names
    transcription repressor of MHCII

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018304.4 → NP_060774.2  proline-rich protein 11

      See identical proteins and their annotated locations for NP_060774.2

      Status: VALIDATED

      Source sequence(s)
      AC099850, AK225377, AW957315, DB106349
      Consensus CDS
      CCDS11614.1
      UniProtKB/Swiss-Prot
      Q96HE9, Q9NUZ7, Q9NXE9
      UniProtKB/TrEMBL
      D2SNZ4
      Related
      ENSP00000262293.5, ENST00000262293.9

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      59155746..59206709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450828.2 → XP_024306596.1  proline-rich protein 11 isoform X1

      UniProtKB/Swiss-Prot
      Q96HE9, Q9NUZ7, Q9NXE9
      UniProtKB/TrEMBL
      D2SNZ4

    2. XM_047436387.1 → XP_047292343.1  proline-rich protein 11 isoform X1

      UniProtKB/Swiss-Prot
      Q96HE9, Q9NUZ7, Q9NXE9
      UniProtKB/TrEMBL
      D2SNZ4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      60023844..60074810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316639.1 → XP_054172614.1  proline-rich protein 11 isoform X1

      UniProtKB/Swiss-Prot
      Q96HE9, Q9NUZ7, Q9NXE9
      UniProtKB/TrEMBL
      D2SNZ4

    2. XM_054316640.1 → XP_054172615.1  proline-rich protein 11 isoform X1

      UniProtKB/Swiss-Prot
      Q96HE9, Q9NUZ7, Q9NXE9
      UniProtKB/TrEMBL
      D2SNZ4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96HE9.1 GenPept UniProtKB/Swiss-Prot:Q96HE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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