TCF7L2 transcription factor 7 like 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TCF7L2provided by HGNC
Official Full Name: transcription factor 7 like 2provided by HGNC
Primary source: HGNC:HGNC:11641
See related: Ensembl:ENSG00000148737 MIM:602228; AllianceGenome:HGNC:11641
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TCF4; TCF-4
Summary: This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Annotation information: Note: TCF4 (Gene ID: 6925) and TCF7L2 (Gene ID: 6934) loci share the TCF4 symbol/alias in common. TCF4 is a widely used alternative name for T-cell-specific transcription factor 4 (TCF7L2) conflicting with the official symbol for transcription factor 4 (TCF4). [08 Feb 2019]
Expression: Ubiquitous expression in fat (RPKM 12.8), colon (RPKM 11.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q25.2-q25.3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (112950247..113167678)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (113841538..114058955)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (114710006..114927437)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans.
Title: The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans.
Haplotype-based association study of TCF7L2 gene variants with the development of diabetic retinopathy in an Iranian population.
Title: Haplotype-based association study of TCF7L2 gene variants with the development of diabetic retinopathy in an Iranian population.
Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway.
Title: Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway.
Astrocytic beta-catenin signaling via TCF7L2 regulates synapse development and social behavior.
Title: Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior.
TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case-Control Study.
Title: TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case-Control Study.
Association of Polymorphic Variants of TCF7L2 and PPARG Genes with Metabolic Markers in Patients with Early Disorders of Carbohydrate Metabolism.
Title: Association of Polymorphic Variants of TCF7L2 and PPARG Genes with Metabolic Markers in Patients with Early Disorders of Carbohydrate Metabolism.
MiR-27a-3p exacerbates cell migration and invasion in right-sided/left-sided colorectal cancer by targeting TGFBR2/TCF7L2.
Title: MiR-27a-3p exacerbates cell migration and invasion in right-sided/left-sided colorectal cancer by targeting TGFBR2/TCF7L2.
Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes.
Title: Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes.
Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis.
Title: Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis.
Association between Transcription Factor 7-Like 2 C/T Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis.
Title: Association between Transcription Factor 7-Like 2 C/T Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis.

Submit: New GeneRIF Correction See all GeneRIFs (644)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Type 2 diabetes mellitus MedGen: C0011860 OMIM: 125853 GeneReviews: WFS1 Spectrum Disorder	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2019-03-27) ClinGen Genome Curation Page Haploinsufficency Little evidence for dosage pathogenicity (Last evaluated 2019-03-27) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study identifies novel risk loci for type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of the metabolic syndrome in Indian Asian men. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. EBI GWAS Catalog EBI GWAS CatalogPubMed
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. EBI GWAS Catalog EBI GWAS CatalogPubMed
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies three novel loci for type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. EBI GWAS Catalog EBI GWAS CatalogPubMed
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. EBI GWAS Catalog EBI GWAS CatalogPubMed
The TCF7L2 diabetes risk variant is associated with HbA&#x02081;(C) levels: a genome-wide association meta-analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of Beta-catenin (CTNNB1) and transcription factor 4 (TCF4) by siRNA enhances HIV-1 transcription in astrocytes	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates the expression of transcription factor 7-like 2 (TCF7L2) in human B cells	PubMed
Tat	tat	Expression of TCF-4 in human astrocytic cells decreased HIV-1 Tat-mediated transcription of the HIV-1 LTR, while GST pull-down assays revealed a direct interaction of Tat with TCF-4, suggesting TCF-4 may regulate the level of HIV-1 gene transcription	PubMed
	tat	TCF4 and beta-catenin proteins inhibit docking of HIV-1 Tat at the TAR region of the HIV-1 LTR	PubMed
	tat	Axin1 regulates HIV-1 Tat-mediated transcription, which requires beta-catenin and TCF4	PubMed
	tat	HIV-1 Tat expression inhibits the TCF-4-induced inhibition of Sp1 phosphorylation and Sp1-mediated HIV-1 LTR transcription	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-T97004 (e-PCR)
- UniSTS:54279

G43540 (e-PCR)
- UniSTS:94995

SHGC-6704 (e-PCR)
- UniSTS:80444

SHGC-58284 (e-PCR)
- UniSTS:41285

RH11324 (e-PCR)
- UniSTS:60237

RH102533 (e-PCR)
- UniSTS:96867

STS-T97004 (e-PCR)
- UniSTS:49779

SHGC-33545 (e-PCR)
- UniSTS:31875

G20756 (e-PCR)
- UniSTS:63111

A006F09 (e-PCR)
- UniSTS:63112

RH66532 (e-PCR)
- UniSTS:48779

D10S168 (e-PCR), detects polymorphism
- UniSTS:28320

RH48450 (e-PCR)
- UniSTS:32199

SHGC-144967 (e-PCR)
- UniSTS:172490

D10S2296 (e-PCR)
- UniSTS:65512

SHGC-112532 (e-PCR)
- UniSTS:168681

WI-20234 (e-PCR)
- UniSTS:4331

STS-T81462 (e-PCR)
- UniSTS:18669

D10S1597 (e-PCR)
- UniSTS:62190

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables armadillo repeat domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	EXP Inferred from Experiment more info	PubMed
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables gamma-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IC Inferred by Curator more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of DNA repeat elements	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fate commitment	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type B pancreatic cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pancreas development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of hormone metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucose	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
part_of beta-catenin-TCF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin-TCF7L2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of catenin-TCF7L2 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor 7-like 2

Names: HMG box transcription factor 4; T-cell factor 4; T-cell-specific transcription factor 4; hTCF-4; transcription factor 7-like 2 (T-cell specific, HMG-box)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012631.1 RefSeqGene

Range

4998..222429

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001146274.2 → NP_001139746.1 transcription factor 7-like 2 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform.

Source sequence(s)

AL158212, AL445486, AL451084

Consensus CDS

CCDS53577.1

UniProtKB/TrEMBL

A0A2Z5HTM8

Related

ENSP00000486891.1, ENST00000627217.3

Conserved Domains (2) summary

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding

cd21996
Location:349 → 433

HMG-box_TCF7-like; high mobility group (HMG)-box found in the transcription factor 7 (TCF-7)-like family
NM_001146283.2 → NP_001139755.1 transcription factor 7-like 2 isoform 3

See identical proteins and their annotated locations for NP_001139755.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL135792, AL158212, AL445486, AL451084

Consensus CDS

CCDS53578.1

UniProtKB/TrEMBL

C6ZRK1

Related

ENSP00000347949.4, ENST00000355717.9

Conserved Domains (2) summary

pfam08347
Location:17 → 283

CTNNB1_binding; N-terminal CTNNB1 binding

cd21996
Location:373 → 457

HMG-box_TCF7-like; high mobility group (HMG)-box found in the transcription factor 7 (TCF-7)-like family
NM_001146284.2 → NP_001139756.1 transcription factor 7-like 2 isoform 4

See identical proteins and their annotated locations for NP_001139756.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 4) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL158212, AL445486, AL451084

UniProtKB/TrEMBL

C6ZRK1

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001146285.2 → NP_001139757.1 transcription factor 7-like 2 isoform 5

See identical proteins and their annotated locations for NP_001139757.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 5, which is shorter than isoform 1.

Source sequence(s)

AL158212, AL445486, AL451084

Consensus CDS

CCDS73197.1

UniProtKB/TrEMBL

C6ZRK5, E2GH23, Q5JRY5

Related

ENSP00000277945.8, ENST00000277945.12

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001146286.2 → NP_001139758.1 transcription factor 7-like 2 isoform 6

See identical proteins and their annotated locations for NP_001139758.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 6) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL158212, AL445486, AL451084

UniProtKB/TrEMBL

C6ZRK1

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001198525.2 → NP_001185454.1 transcription factor 7-like 2 isoform 7

See identical proteins and their annotated locations for NP_001185454.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 7) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL158212, AL451084, DA473655, FJ010166, FJ010170

Consensus CDS

CCDS73196.1

UniProtKB/TrEMBL

C6ZRJ7, C6ZRK1

Related

ENSP00000440547.2, ENST00000545257.6

Conserved Domains (2) summary

cd01388
Location:335 → 402

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001198526.2 → NP_001185455.1 transcription factor 7-like 2 isoform 8

See identical proteins and their annotated locations for NP_001185455.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 8, which is shorter than isoform 1.

Source sequence(s)

AL158212, AL451084, DA473655, FJ010167

UniProtKB/TrEMBL

E2GH23

Related

ENSP00000487507.1, ENST00000629706.2

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001198527.2 → NP_001185456.1 transcription factor 7-like 2 isoform 9

See identical proteins and their annotated locations for NP_001185456.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 9) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL158212, AL451084, DA473655, FJ010168

Consensus CDS

CCDS81504.1

UniProtKB/TrEMBL

C6ZRJ9, C6ZRK1, Q5VVR7

Related

ENSP00000358402.2, ENST00000369395.6

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001198528.2 → NP_001185457.1 transcription factor 7-like 2 isoform 10

See identical proteins and their annotated locations for NP_001185457.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 10) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL158212, AL451084, DA473655, FJ010169

Consensus CDS

CCDS55729.1

UniProtKB/TrEMBL

C6ZRK1

Related

ENSP00000344823.5, ENST00000352065.10

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001198529.2 → NP_001185458.1 transcription factor 7-like 2 isoform 11

See identical proteins and their annotated locations for NP_001185458.1

Status: REVIEWED

Description

Transcript Variant: This variant (11) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 11) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL158212, AL451084, DA473655, FJ010170

Consensus CDS

CCDS91349.1

UniProtKB/TrEMBL

A0A994J711, C6ZRK1

Related

ENSP00000515891.1, ENST00000704414.1

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001198530.2 → NP_001185459.1 transcription factor 7-like 2 isoform 12

See identical proteins and their annotated locations for NP_001185459.1

Status: REVIEWED

Description

Transcript Variant: This variant (12) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 12) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL158212, AL451084, DA473655, FJ010171

Consensus CDS

CCDS73198.1

UniProtKB/TrEMBL

A0A0A0MTL7, C6ZRK2

Related

ENSP00000443626.2, ENST00000534894.5

Conserved Domains (2) summary

cd01388
Location:296 → 363

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 202

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001198531.2 → NP_001185460.1 transcription factor 7-like 2 isoform 13

See identical proteins and their annotated locations for NP_001185460.1

Status: REVIEWED

Description

Transcript Variant: This variant (13) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 13) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AB440195, AL158212, AL451084, DA473655

UniProtKB/TrEMBL

E2GH15

Conserved Domains (2) summary

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding

cd21996
Location:349 → 433

HMG-box_TCF7-like; high mobility group (HMG)-box found in the transcription factor 7 (TCF-7)-like family
NM_001349870.2 → NP_001336799.1 transcription factor 7-like 2 isoform 14

Status: REVIEWED

Description

Transcript Variant: This variant (14) lacks alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (14) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AL451084

UniProtKB/TrEMBL

A0A1B0GVE1, B4DJZ2

Related

ENSP00000490478.2, ENST00000637574.2

Conserved Domains (2) summary

cd01388
Location:210 → 277

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:42 → 116

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001349871.1 → NP_001336800.1 transcription factor 7-like 2 isoform 15

Status: REVIEWED

Description

Transcript Variant: This variant (15) lacks alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (15) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AL135792, AL451084

Consensus CDS

CCDS91350.1

UniProtKB/TrEMBL

B7Z9Z6, Q5JRY4, Q5VVR8

Related

ENSP00000358396.3, ENST00000369389.7

Conserved Domains (2) summary

cd01388
Location:170 → 237

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001363501.2 → NP_001350430.1 transcription factor 7-like 2 isoform 16

Status: REVIEWED

Source sequence(s)

AL158212, AL445486, AL451084

Consensus CDS

CCDS86148.1

UniProtKB/TrEMBL

E2GH15

Related

ENSP00000446172.1, ENST00000538897.5

Conserved Domains (2) summary

cd01388
Location:353 → 420

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001367943.1 → NP_001354872.1 transcription factor 7-like 2 isoform 17

Status: REVIEWED

Source sequence(s)

BC032656, BM701919, BQ900611, BU619467, DA394991, DA590466, HM352850, Z99386

Consensus CDS

CCDS91348.1

UniProtKB/Swiss-Prot

B4DRJ8, B9X074, C6ZRJ8, C6ZRK0, E2GH14, E2GH19, E2GH20, E2GH24, E2GH25, E9PFH9, F8W742, F8W7T5, O00185, Q9NQB0, Q9NQB1, Q9NQB2, Q9NQB3, Q9NQB4, Q9NQB5, Q9NQB6, Q9NQB7, Q9ULC2

UniProtKB/TrEMBL

E2GH23

Related

ENSP00000348274.4, ENST00000355995.9

Conserved Domains (2) summary

cd01388
Location:353 → 420

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
NM_030756.5 → NP_110383.2 transcription factor 7-like 2 isoform 2

See identical proteins and their annotated locations for NP_110383.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AL158212, AL445486, AL451084

Consensus CDS

CCDS7576.1

UniProtKB/TrEMBL

E2GH23, Q6FHW4

Related

ENSP00000358404.4, ENST00000369397.8

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding