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    MAST3 microtubule associated serine/threonine kinase 3 [ Homo sapiens (human) ]

    Gene ID: 23031, updated on 27-Nov-2024

    Summary

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    Official Symbol
    MAST3provided by HGNC
    Official Full Name
    microtubule associated serine/threonine kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:19036
    See related
    Ensembl:ENSG00000099308 MIM:612258; AllianceGenome:HGNC:19036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DEE108
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization and intracellular signal transduction. Predicted to be located in cytoplasm. Implicated in developmental and epileptic encephalopathy 108. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in brain (RPKM 16.8), spleen (RPKM 6.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MAST3 in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (18097778..18151687)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (18231851..18285787)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18208588..18262497)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NAD(P)HX epimerase pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:18160178-18160339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18162377-18162878 Neighboring gene ribosomal protein S18 pseudogene 13 Neighboring gene Sharpr-MPRA regulatory region 12288 Neighboring gene interleukin 12 receptor subunit beta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10368 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10369 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18220925-18221494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18228711-18229582 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:18232970-18234169 Neighboring gene uncharacterized LOC124904650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18256091-18256592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18256593-18257093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14300 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18263346-18264238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18267436-18268294 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:18270202-18270406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18271190-18271739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10375 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18285185-18285850 Neighboring gene IFI30 lysosomal thiol reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MAST3: a novel IBD risk factor that modulates TLR4 signaling. Labbé C, et al. Genes Immun, 2008 Oct. PMID 18650832, Free PMC Article
    2. MiR-125a-3p inhibits cell proliferation and inflammation responses in fibroblast-like synovial cells in rheumatoid arthritis by mediating the Wnt/β-catenin and NF-κB pathways via targeting MAST3. Wang Y, et al. J Musculoskelet Neuronal Interact, 2021 Dec 1. PMID 34854396, Free PMC Article
    3. Pathogenic MAST3 Variants in the STK Domain Are Associated with Epilepsy. Spinelli E, et al. Ann Neurol, 2021 Aug. PMID 34185323, Free PMC Article
    4. Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. Musante V, et al. Elife, 2017 Jun 14. PMID 28613156, Free PMC Article
    5. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. Valiente M, et al. J Biol Chem, 2005 Aug 12. PMID 15951562

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-125a-3p inhibits cell proliferation and inflammation responses in fibroblast-like synovial cells in rheumatoid arthritis by mediating the Wnt/beta-catenin and NF-kappaB pathways via targeting MAST3.
      Title: MiR-125a-3p inhibits cell proliferation and inflammation responses in fibroblast-like synovial cells in rheumatoid arthritis by mediating the Wnt/β-catenin and NF-κB pathways via targeting MAST3.
    2. Pathogenic MAST3 Variants in the STK Domain Are Associated with Epilepsy.
      Title: Pathogenic MAST3 Variants in the STK Domain Are Associated with Epilepsy.
    3. Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A disinhibition.
      Title: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition.
    4. A single-nucleotide polymorphism (SNP)located in the second intron of the MAST3 gene is found to be associated in the screening and replication inflammatory bowel disease cohorts.
      Title: MAST3: a novel IBD risk factor that modulates TLR4 signaling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Developmental and epileptic encephalopathy 108
    MedGen: C5774253 OMIM: 620115 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0561

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated serine/threonine-protein kinase 3
    NP_001380430.1
    NP_001380431.1
    NP_001380432.1
    NP_001380433.1
    NP_001380434.1
    NP_001380435.1
    NP_001380436.1
    NP_001380437.1
    NP_001380438.1
    NP_001380439.1
    NP_001380440.1
    NP_001380441.1
    NP_001380442.1
    NP_001380443.1
    NP_001380444.1
    NP_001380445.1
    NP_001380446.1
    NP_001380447.1
    NP_001380448.1
    NP_001380449.1
    NP_001380450.1
    NP_055831.1
    XP_006722762.2
    XP_016881995.1
    XP_016881996.1
    XP_016881997.1
    XP_016881998.1
    XP_016881999.1
    XP_016882005.1
    XP_047294429.1
    XP_047294430.1
    XP_047294431.1
    XP_047294432.1
    XP_047294433.1
    XP_047294434.1
    XP_047294435.1
    XP_047294436.1
    XP_047294437.1
    XP_047294438.1
    XP_047294439.1
    XP_047294440.1
    XP_047294441.1
    XP_054176266.1
    XP_054176267.1
    XP_054176268.1
    XP_054176269.1
    XP_054176270.1
    XP_054176271.1
    XP_054176272.1
    XP_054176273.1
    XP_054176274.1
    XP_054176275.1
    XP_054176276.1
    XP_054176277.1
    XP_054176278.1
    XP_054176279.1
    XP_054176280.1
    XP_054176281.1
    XP_054176282.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393501.1 → NP_001380430.1  microtubule-associated serine/threonine-protein kinase 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC020904, AC093054
      Conserved Domains (3) summary
      smart00228
      Location:988 → 1069
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:403 → 682
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:88 → 368
      DUF1908; Domain of unknown function (DUF1908)

    2. NM_001393502.1 → NP_001380431.1  microtubule-associated serine/threonine-protein kinase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC020904, AC093054
      Conserved Domains (2) summary
      smart00228
      Location:981 → 1062
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:396 → 675
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    3. NM_001393503.1 → NP_001380432.1  microtubule-associated serine/threonine-protein kinase 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC093054
      Conserved Domains (3) summary
      smart00228
      Location:980 → 1061
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:395 → 674
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:80 → 360
      DUF1908; Domain of unknown function (DUF1908)

    4. NM_001393504.1 → NP_001380433.1  microtubule-associated serine/threonine-protein kinase 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC020904, AC093054
      Consensus CDS
      CCDS92564.1
      UniProtKB/TrEMBL
      A0A8I5KST9
      Related
      ENSP00000509890.1, ENST00000687212.1
      Conserved Domains (2) summary
      smart00228
      Location:980 → 1061
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:395 → 674
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    5. NM_001393505.1 → NP_001380434.1  microtubule-associated serine/threonine-protein kinase 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC093054
      Conserved Domains (2) summary
      smart00228
      Location:979 → 1060
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:394 → 673
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    6. NM_001393506.1 → NP_001380435.1  microtubule-associated serine/threonine-protein kinase 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC093054
      Conserved Domains (3) summary
      smart00228
      Location:964 → 1045
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:379 → 658
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:64 → 344
      DUF1908; Domain of unknown function (DUF1908)

    7. NM_001393507.1 → NP_001380436.1  microtubule-associated serine/threonine-protein kinase 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC093054
      Consensus CDS
      CCDS92565.1
      UniProtKB/TrEMBL
      A0A8V8TLL8
      Related
      ENSP00000513408.1, ENST00000697701.1
      Conserved Domains (2) summary
      smart00228
      Location:973 → 1054
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:388 → 667
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    8. NM_001393508.1 → NP_001380437.1  microtubule-associated serine/threonine-protein kinase 3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC020904, AC093054
      Conserved Domains (3) summary
      smart00228
      Location:958 → 1039
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:373 → 652
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:58 → 338
      DUF1908; Domain of unknown function (DUF1908)

    9. NM_001393509.1 → NP_001380438.1  microtubule-associated serine/threonine-protein kinase 3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC020904, AC093054
      Conserved Domains (3) summary
      smart00228
      Location:957 → 1038
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:372 → 651
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:57 → 337
      DUF1908; Domain of unknown function (DUF1908)

    10. NM_001393510.1 → NP_001380439.1  microtubule-associated serine/threonine-protein kinase 3 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC093054
      Conserved Domains (2) summary
      smart00228
      Location:957 → 1038
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:372 → 651
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    11. NM_001393511.1 → NP_001380440.1  microtubule-associated serine/threonine-protein kinase 3 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC093054
      Conserved Domains (3) summary
      smart00228
      Location:956 → 1037
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:371 → 650
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:63 → 336
      DUF1908; Domain of unknown function (DUF1908)

    12. NM_001393512.1 → NP_001380441.1  microtubule-associated serine/threonine-protein kinase 3 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC020904, AC093054
      Conserved Domains (2) summary
      smart00228
      Location:957 → 1038
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:372 → 651
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    13. NM_001393513.1 → NP_001380442.1  microtubule-associated serine/threonine-protein kinase 3 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC093054
      Conserved Domains (2) summary
      smart00228
      Location:964 → 1045
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:379 → 658
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    14. NM_001393514.1 → NP_001380443.1  microtubule-associated serine/threonine-protein kinase 3 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC020904, AC093054
      Conserved Domains (3) summary
      smart00228
      Location:951 → 1032
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:366 → 645
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:58 → 331
      DUF1908; Domain of unknown function (DUF1908)

    15. NM_001393515.1 → NP_001380444.1  microtubule-associated serine/threonine-protein kinase 3 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC020904, AC093054
      Conserved Domains (3) summary
      smart00228
      Location:950 → 1031
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:365 → 644
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:57 → 330
      DUF1908; Domain of unknown function (DUF1908)

    16. NM_001393516.1 → NP_001380445.1  microtubule-associated serine/threonine-protein kinase 3 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC020904, AC093054
      Conserved Domains (2) summary
      smart00228
      Location:958 → 1039
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:373 → 652
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    17. NM_001393517.1 → NP_001380446.1  microtubule-associated serine/threonine-protein kinase 3 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC093054
      Consensus CDS
      CCDS92566.1
      UniProtKB/TrEMBL
      A0A8V8TMW0
      Related
      ENSP00000513409.1, ENST00000697702.1
      Conserved Domains (3) summary
      smart00228
      Location:957 → 1038
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:372 → 651
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:64 → 337
      DUF1908; Domain of unknown function (DUF1908)

    18. NM_001393518.1 → NP_001380447.1  microtubule-associated serine/threonine-protein kinase 3 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC020904, AC093054
      Conserved Domains (2) summary
      smart00228
      Location:957 → 1038
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:372 → 651
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    19. NM_001393519.1 → NP_001380448.1  microtubule-associated serine/threonine-protein kinase 3 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC093054
      Conserved Domains (3) summary
      smart00228
      Location:956 → 1037
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:371 → 650
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:63 → 336
      DUF1908; Domain of unknown function (DUF1908)

    20. NM_001393520.1 → NP_001380449.1  microtubule-associated serine/threonine-protein kinase 3 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC020904, AC093054
      Conserved Domains (2) summary
      smart00228
      Location:950 → 1031
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:365 → 644
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    21. NM_001393521.1 → NP_001380450.1  microtubule-associated serine/threonine-protein kinase 3 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC005793, AC007192, AC093054
      Conserved Domains (2) summary
      smart00228
      Location:942 → 1023
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:357 → 636
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    22. NM_015016.2 → NP_055831.1  microtubule-associated serine/threonine-protein kinase 3 isoform 20

      See identical proteins and their annotated locations for NP_055831.1

      Status: VALIDATED

      Source sequence(s)
      AB011133, AC020904, BI907332, BQ340083, DA134568
      Consensus CDS
      CCDS46014.1
      UniProtKB/Swiss-Prot
      O60307, Q7LDZ8, Q9UPI0
      Related
      ENSP00000262811.4, ENST00000262811.10
      Conserved Domains (4) summary
      smart00220
      Location:367 → 640
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00228
      Location:951 → 1032
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:366 → 645
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:58 → 331
      DUF1908; Domain of unknown function (DUF1908)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      18097778..18151687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438476.1 → XP_047294432.1  microtubule-associated serine/threonine-protein kinase 3 isoform X11

    2. XM_047438480.1 → XP_047294436.1  microtubule-associated serine/threonine-protein kinase 3 isoform X15

    3. XM_047438474.1 → XP_047294430.1  microtubule-associated serine/threonine-protein kinase 3 isoform X9

    4. XM_047438477.1 → XP_047294433.1  microtubule-associated serine/threonine-protein kinase 3 isoform X12

    5. XM_047438482.1 → XP_047294438.1  microtubule-associated serine/threonine-protein kinase 3 isoform X17

    6. XM_006722699.3 → XP_006722762.2  microtubule-associated serine/threonine-protein kinase 3 isoform X1

      Conserved Domains (4) summary
      smart00220
      Location:468 → 741
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00228
      Location:1052 → 1133
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:467 → 746
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:152 → 432
      DUF1908; Domain of unknown function (DUF1908)

    7. XM_017026509.2 → XP_016881998.1  microtubule-associated serine/threonine-protein kinase 3 isoform X5

    8. XM_017026507.2 → XP_016881996.1  microtubule-associated serine/threonine-protein kinase 3 isoform X3

    9. XM_017026510.3 → XP_016881999.1  microtubule-associated serine/threonine-protein kinase 3 isoform X7

    10. XM_017026506.2 → XP_016881995.1  microtubule-associated serine/threonine-protein kinase 3 isoform X2

    11. XM_017026516.2 → XP_016882005.1  microtubule-associated serine/threonine-protein kinase 3 isoform X6

    12. XM_017026508.2 → XP_016881997.1  microtubule-associated serine/threonine-protein kinase 3 isoform X4

    13. XM_047438473.1 → XP_047294429.1  microtubule-associated serine/threonine-protein kinase 3 isoform X8

    14. XM_047438481.1 → XP_047294437.1  microtubule-associated serine/threonine-protein kinase 3 isoform X16

    15. XM_047438478.1 → XP_047294434.1  microtubule-associated serine/threonine-protein kinase 3 isoform X13

    16. XM_047438475.1 → XP_047294431.1  microtubule-associated serine/threonine-protein kinase 3 isoform X10

    17. XM_047438479.1 → XP_047294435.1  microtubule-associated serine/threonine-protein kinase 3 isoform X14

    18. XM_047438484.1 → XP_047294440.1  microtubule-associated serine/threonine-protein kinase 3 isoform X19

    19. XM_047438483.1 → XP_047294439.1  microtubule-associated serine/threonine-protein kinase 3 isoform X18

    20. XM_047438485.1 → XP_047294441.1  microtubule-associated serine/threonine-protein kinase 3 isoform X20

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      18231851..18285787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320295.1 → XP_054176270.1  microtubule-associated serine/threonine-protein kinase 3 isoform X11

    2. XM_054320300.1 → XP_054176275.1  microtubule-associated serine/threonine-protein kinase 3 isoform X15

    3. XM_054320291.1 → XP_054176266.1  microtubule-associated serine/threonine-protein kinase 3 isoform X9

    4. XM_054320296.1 → XP_054176271.1  microtubule-associated serine/threonine-protein kinase 3 isoform X12

    5. XM_054320302.1 → XP_054176277.1  microtubule-associated serine/threonine-protein kinase 3 isoform X17

    6. XM_054320292.1 → XP_054176267.1  microtubule-associated serine/threonine-protein kinase 3 isoform X21

    7. XM_054320297.1 → XP_054176272.1  microtubule-associated serine/threonine-protein kinase 3 isoform X23

    8. XM_054320303.1 → XP_054176278.1  microtubule-associated serine/threonine-protein kinase 3 isoform X24

    9. XM_054320293.1 → XP_054176268.1  microtubule-associated serine/threonine-protein kinase 3 isoform X22

    10. XM_054320304.1 → XP_054176279.1  microtubule-associated serine/threonine-protein kinase 3 isoform X25

    11. XM_054320301.1 → XP_054176276.1  microtubule-associated serine/threonine-protein kinase 3 isoform X16

    12. XM_054320298.1 → XP_054176273.1  microtubule-associated serine/threonine-protein kinase 3 isoform X13

    13. XM_054320294.1 → XP_054176269.1  microtubule-associated serine/threonine-protein kinase 3 isoform X10

    14. XM_054320299.1 → XP_054176274.1  microtubule-associated serine/threonine-protein kinase 3 isoform X14

    15. XM_054320306.1 → XP_054176281.1  microtubule-associated serine/threonine-protein kinase 3 isoform X19

    16. XM_054320305.1 → XP_054176280.1  microtubule-associated serine/threonine-protein kinase 3 isoform X18

    17. XM_054320307.1 → XP_054176282.1  microtubule-associated serine/threonine-protein kinase 3 isoform X20

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60307.2 GenPept UniProtKB/Swiss-Prot:O60307

    Gene LinkOut

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