PPP2R3A protein phosphatase 2 regulatory subunit B''alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPP2R3Aprovided by HGNC
Official Full Name: protein phosphatase 2 regulatory subunit B''alphaprovided by HGNC
Primary source: HGNC:HGNC:9307
See related: Ensembl:ENSG00000073711 MIM:604944; AllianceGenome:HGNC:9307
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PR72; PR130; PPP2R3
Summary: This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
Expression: Broad expression in heart (RPKM 10.6), kidney (RPKM 9.3) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q22.2-q22.3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (135965728..136147894)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (138711499..138893700)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (135684570..135866736)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Protein Phosphatase 2 Regulatory Subunit B""Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma.
Title: Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma.
A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies.
Title: A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies.
The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation.
Title: The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation.
[Functional Hypermethylation of ALDH1L1, PLCL2, and PPP2R3A in Colon Cancer].
Title: [Functional Hypermethylation of ALDH1L1, PLCL2, and PPP2R3A in Colon Cancer].
HDAC1 and HDAC2 suppress the expression of PPP2R3A/PR130, a regulatory subunit of the trimeric serine/threonine phosphatase 2 (PP2A).
Title: HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.
this study shows the importance of PP2A complexes with the LIM domains of lipoma-preferred partner in cell adhesion and migration dynamics
Title: PP2A binds to the LIM domains of lipoma-preferred partner through its PR130/B″ subunit to regulate cell adhesion and migration.
PP2A can be targeted in a calcium-regulated manner to Cdc6 via the PR70 subunit, where it plays a role in regulating protein phosphorylation and stability.
Title: Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit.
The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.
Title: The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.
two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A demonstrating the ability or calcium ions to interact with and regulate PP2A
Title: Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A.
PR72 interacts physically and functionally with Naked cuticle. PR72, like Naked cuticle, acts as a negative regulator of the classical Wnt signaling cascade.
Title: PR72, a novel regulator of Wnt signaling required for Naked cuticle function.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of the Protein C anticoagulant pathway. EBI GWAS Catalog EBI GWAS CatalogPubMed
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells	PubMed
	tat	Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9	PubMed
	tat	An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression	PubMed
Vpr	vpr	Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain	PubMed
	vpr	HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues	PubMed
	vpr	HIV-1 Vpr was found to upregulate PP2A in fission yeast	PubMed
	vpr	HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A	PubMed
nucleocapsid	gag	HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3S3343 (e-PCR)
- UniSTS:71973

STS-R74400 (e-PCR)
- UniSTS:60242

STS-N32916 (e-PCR)
- UniSTS:6248

RH17602 (e-PCR)
- UniSTS:8582

RH80956 (e-PCR)
- UniSTS:88743

RH78965 (e-PCR)
- UniSTS:23237

WI-14084 (e-PCR)
- UniSTS:62413

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in eye photoreceptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration involved in somitogenic axis elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration involved in somitogenic axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in somatic muscle development	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic muscle development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in somite development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in somitogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 2A complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

Names: PR130/B''alpha1 subunit; PR72/B''alpha2 subuit; protein phosphatase 2, regulatory subunit B'', alpha; serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B

NP_001177376.1

EC 3.1.3.16

NP_002709.2

EC 3.1.3.16

NP_871626.1

EC 3.1.3.16

XP_006713749.1

EC 3.1.3.16

XP_011511258.1

EC 3.1.3.16

XP_016862276.1

EC 3.1.3.16

XP_047304465.1

EC 3.1.3.16

XP_047304466.1

EC 3.1.3.16

XP_054203133.1

EC 3.1.3.16

XP_054203134.1

EC 3.1.3.16

XP_054203135.1

EC 3.1.3.16

XP_054203136.1

EC 3.1.3.16

XP_054203137.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029234.1 RefSeqGene

Range

5056..187222

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001190447.2 → NP_001177376.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 3

See identical proteins and their annotated locations for NP_001177376.1

Status: REVIEWED

Description

Transcript Variant: variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK298059, AL389975, DB223168, DB378665

Consensus CDS

CCDS54642.1

UniProtKB/Swiss-Prot

Q06190

Related

ENSP00000419344.1, ENST00000490467.5

Conserved Domains (1) summary

pfam13499
Location:167 → 265

EF-hand_7; EF-hand domain pair
NM_002718.5 → NP_002709.2 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1

See identical proteins and their annotated locations for NP_002709.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as isoform beta or isoform PR130.

Source sequence(s)

AK293012, AL389975, DB378665

Consensus CDS

CCDS3087.1

UniProtKB/Swiss-Prot

A8KAE7, B4DNU1, B7ZAE3, Q06189, Q06190, Q9NPQ5

UniProtKB/TrEMBL

B2RAL3, Q6P0N9

Related

ENSP00000264977.3, ENST00000264977.8

Conserved Domains (1) summary

pfam13499
Location:903 → 1001

EF-hand_7; EF-hand domain pair
NM_181897.3 → NP_871626.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

See identical proteins and their annotated locations for NP_871626.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (2), also known as isoform alpha or isoform PR72, contains a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC072039, AK316258, AL389975, DB378665

Consensus CDS

CCDS3088.1

UniProtKB/TrEMBL

B4DS28

Related

ENSP00000334748.2, ENST00000334546.6

Conserved Domains (1) summary

pfam13499
Location:282 → 380

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

135965728..136147894

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017006787.3 → XP_016862276.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

UniProtKB/TrEMBL

B2RAL3, Q6P0N9
XM_006713686.5 → XP_006713749.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1

See identical proteins and their annotated locations for XP_006713749.1

UniProtKB/Swiss-Prot

A8KAE7, B4DNU1, B7ZAE3, Q06189, Q06190, Q9NPQ5

UniProtKB/TrEMBL

B2RAL3, Q6P0N9

Conserved Domains (1) summary

pfam13499
Location:903 → 1001

EF-hand_7; EF-hand domain pair
XM_047448510.1 → XP_047304466.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2
XM_011512956.4 → XP_011511258.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1

See identical proteins and their annotated locations for XP_011511258.1

UniProtKB/Swiss-Prot

A8KAE7, B4DNU1, B7ZAE3, Q06189, Q06190, Q9NPQ5

UniProtKB/TrEMBL

B2RAL3, Q6P0N9

Conserved Domains (1) summary

pfam13499
Location:903 → 1001

EF-hand_7; EF-hand domain pair
XM_047448509.1 → XP_047304465.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

RNA

XR_001740196.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

138711499..138893700

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054347160.1 → XP_054203135.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2
XM_054347158.1 → XP_054203133.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1
XM_054347159.1 → XP_054203134.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1
XM_054347162.1 → XP_054203137.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2
XM_054347161.1 → XP_054203136.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2