Slc22a14 solute carrier family 22 (organic cation transporter), member 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc22a14provided by MGI
Official Full Name: solute carrier family 22 (organic cation transporter), member 14provided by MGI
Primary source: MGI:MGI:2685974
See related: Ensembl:ENSMUSG00000070280 AllianceGenome:MGI:2685974
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1128
Summary: Enables riboflavin transmembrane transporter activity. Acts upstream of or within flagellated sperm motility and sperm capacitation. Located in sperm principal piece. Is active in mitochondrial inner membrane. Orthologous to human SLC22A14 (solute carrier family 22 member 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 114.3) See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 71.33 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (118998521..119019496, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (119169453..119190430, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of Slc22a14 found that Slc22a14-deficient male mice showed severe infertility. Although the differentiation process in testis appeared to be normal, cauda epididymal spermatozoa in Slc22a14-/- mice showed impaired motility with abnormal tails.
Title: A critical role of solute carrier 22a14 in sperm motility and male fertility in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

Slc22a14 (e-PCR), detects polymorphism
- UniSTS:547020

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables riboflavin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables riboflavin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in riboflavin transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sperm capacitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sperm principal piece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: solute carrier family 22 member 14

Names: organic cation transporter like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.