Dnaaf6rt dynein axonemal assembly factor 6, retrotransposed [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnaaf6rtprovided by MGI
Official Full Name: dynein axonemal assembly factor 6, retrotransposedprovided by MGI
Primary source: MGI:MGI:1921958
See related: Ensembl:ENSMUSG00000026063 AllianceGenome:MGI:1921958
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dnaaf6; Pih1d3; 4930521A18Rik
Summary: Enables protein-folding chaperone binding activity. Acts upstream of or within axonemal dynein complex assembly and flagellated sperm motility. Located in cytoplasm. Is expressed in spermatid; spermatocyte; and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 36. Orthologous to human DNAAF6 (dynein axonemal assembly factor 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 1 B; 1 11.56 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (31261920..31263368)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (31222839..31224287)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pih1d3 contributes to cytoplasmic preassembly of dynein complexes in spermatogenic cells by stabilizing and promoting complex formation by ODA and IDA proteins.
Title: Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

BB015332 (e-PCR)
- UniSTS:207142

NoName (e-PCR)
- UniSTS:488911

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	ISO Inferred from Sequence Orthology more info
enables dynein intermediate chain binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axonemal dynein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonemal dynein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonemal dynein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in axonemal dynein complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium movement	ISO Inferred from Sequence Orthology more info
involved_in cilium movement	ISS Inferred from Sequence or Structural Similarity more info
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in inner dynein arm assembly	ISO Inferred from Sequence Orthology more info
involved_in inner dynein arm assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in outer dynein arm assembly	ISO Inferred from Sequence Orthology more info
involved_in outer dynein arm assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dynein axonemal assembly factor 6

Names: PIH1 domain containing 3; PIH1 domain-containing protein 3; dynein assembly factor 6, axonemal; protein PIH1D3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029062.2 → NP_083338.1 dynein axonemal assembly factor 6

See identical proteins and their annotated locations for NP_083338.1

Status: VALIDATED

Source sequence(s)

AK015858

Consensus CDS

CCDS35531.1

UniProtKB/Swiss-Prot

Q3KNI6

Related

ENSMUSP00000127665.2, ENSMUST00000027230.3

Conserved Domains (1) summary

cl00175
Location:146 → 209

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.